It was founded in 1859 by former komusubi Arakuma. It was led from 1929 by former sekiwake Kiyosegawa. His daughter married the sixth head, the 38th yokozuna Terukuni Manzō who led the stable from 1961 until his death in 1977. He had already made arrangements to pass control over to former ōzeki Kiyokuni Katsuo before his death. After Kiyokuni's wife and children were killed in the Japan Airlines Flight 123 crash in 1985, the stable began to decline. He remarried and moved the heya's location, but his new wife was not as interested in helping to run the heya. Its last sekitori, Wakasegawa, retired in 1992, and recruitment suffered. By the end only two active wrestlers remained.
A different incarnation of Isegahama stable was founded as Ajigawa stable in 1979, before being re-named by yokozuna Asahifuji in November 2007. Asahifuji's decision to switch to the Isegahama name can be seen as an attempt to restore his ichimon's reputation (the ichimon was known as Tatsunami-Isegahama for many years before becoming solely Tatsunami; as a result of the success of the renamed stable the ichimon is now solely known as Isegahama).
- Terukuni Manzō (yokozuna)
- Kiyokuni Katsuo (ozeki)
- Bishūyama Jun'ichi (sekiwake)
- Kairyūyama Teruhisa (sekiwake)
- Kurosegawa Kuniyuki (komusubi)
- Saisu Minoru (maegashira)
- Wakasegawa Yoshimitsu (maegashira)