|Great Royal Wife|
Lady of The Two Lands
Mistress of Upper and Lower Egypt
Queen of Egypt
|Dynasty||Nineteenth of Egypt|
|Religion||Ancient Egyptian religion|
Her children include:
- Prince Sety-Merenptah, who later would assume the throne as Seti II
- Prince Merenptah, King's Son, Executive at the Head of the Two Lands, and Generalissimo 
- Prince Khaemwaset, King's Son, Depicted in Karnak Temple 
- possibly, Princess Isetnofret (?), King's daughter mentioned in the Leiden ship log 
The titles of Isetnofret II include: Lady of The Two Lands (nbt-t3wy), Great King’s Wife (hmt-niswt-wrt), Mistress of Upper and Lower Egypt (hnwt-Shm’w -mhw), King’s Wife (hmt-nisw).
Isetnofret II grew up during the reign of Ramesses II, her possible grandfather. If she was the daughter of Khaemwaset, she may have grown up in Memphis, otherwise, she grew up in Piramesse.
Isetnofret II is attested several times during the reign of her husband:
- She is depicted on a statue usurped from Amenhotep III by Merenptah.
- A stela of the Vizier Panehesy at Gebel el Silsila also depicts her. This stela is situated across the Chapel of Panehesy and depicts Merneptah, Queen Isetnofret, Sety-Merneptah, and the vizier, before Amun-Re and Ptah.
- Another stela situated in the Gallery of the Speos of Horemheb at Gebel el Silsila depicts Merenptah followed by Queen Isetnofret and the vizier Panehesy as they offer an image of the goddess Ma'at to Amen-Re and Mut.
- A statuette dedicated by the Vizier Panehesy at Gebel el Silsila also depicts her.
It is not known when or where Isetnofret II died or where she was buried. If Isetnofret was the daughter of Khaemwaset, she may have been buried at Saqqara. The tomb of a royal lady named Isetnofret was discovered in Saqqara during 2009 excavations by Waseda University.
- Aidan Dodson & Dyan Hilton, The Complete Royal Families of Ancient Egypt, Thames & Hudson (2004), p. 178, 183
- Dodson & Hilton, p.178, 182
- Aidan Dodson & Dyan Hilton, The Complete Royal Families of Ancient Egypt, Thames & Hudson (2004), p.178
- W. Grajetzki, Ancient Egyptian Queens: a hieroglyphic dictionary.
- Dodson & Hilton, p.182
- Porter and Moss Topographical Bibliography; Volume V Upper Egypt Griffith Institute, p.210
- Porter and Moss Topographical Bibliography; Volume V Upper Egypt Griffith Institute. p.212
- Tomb of Isetnofret Discovered in Saqqara Archived 2009-03-09 at the Wayback Machine