The 1991 national population census estimated the population of the district at about 226,400. In 2002, the population of Isingiro District was recorded at approximately 316,000 with a population growth rate of approximately 3.0% annually. It is estimated that in 2012, the district population was about 420,200.
Gordon Wavamunno, an entrepreneur, businessman, and philanthropist. He is reported to be one of the wealthiest people in Uganda and is the chancellor of Nkumba University.
Benon Biraaro, a retired military officer, entrepreneur, and aspiring politician.
Bright Rwamirama, a retired military officer and politician. State Minister for Animal Industry in the Ugandan Cabinet. Also serves as the elected member of parliament representing Isingiro County North in Isingiro District.