Isochem company

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Industry Chemicals and Speciality Products
Founded 1974
Headquarters Vert-le-Petit, France
Key people
Björn Schlosser (CEO)
Products Chemicals
Number of employees
330 (2016)

Isochem is a French chemicals company specialized in custom synthesis. The company's products and services are primarily destined for the following market sectors:

  • pharmaceuticals (APIs or active ingredients for medicinal products and intermediates),
  • cosmetics
  • specialty chemicals.

The company operates from four production sites in France and also has: one industrial subsidiary outside France: Wychem in the UK.


  • 1974 : Isochem created in Gennevilliers
  • 1977 : Pithiviers (ex. Agrifarm) site opened
  • 1979 : 1st U.S. Food and Drug Administration (FDA) audit and approval; export market development
  • 1990 : Isochem joins Groupe SNPE (fr)
  • 1991 : Isochem acquires the Vert-le-Petit site (ex IRCHA Fine Chemicals and Propeptide)[1]
  • 2003 : acquisition of the Pont-de-Claix platform and the Hungarian subsidiary Framochem
  • 2010 : acquisition of Isochem by the German industrial holding company Aurelius AG (de)[2]
  • 2012 : acquisition of Wychem (UK) by Isochem [3],[4]
  • 2014 : sale of Framochem subsidiary by Isochem
  • 2016 : sale of Wychem subsidiary by Isochem

Initially specialized in the extraction and hemisynthesis of natural substances such as quinine, Isochem has gradually expanded its expertise in the field of multi-step industrial production [5] encompassing a variety of operations including Grignard, Friedel-Crafts, Sandmeyer, Vilsmeier-Haack Reaction, deprotonation using butyllithium, reduction using metal hydrides and hydrogenation.[6]

In the 1990s, synergies with groupe SNPE enabled Isochem to implement new technologies such as phosgenation,[7] nitration and manufacture of amino-acid derivatives such as NCAs[8],[9] UNCAs and peptides.[10],[11]

Industrial sites and specific expertise[edit]

Four sites in France:

Most industrial sites have a research and development team; in addition, the Vert-le-Petit site has the equipment required to study process safety.[14]


  1. ^ Infogreffe Isochem
  2. ^ [1], Isochem cherche des chemins pour grandir, Industrie Pharma, octobre, 2010.
  3. ^ [2], Isochem rachète la société britannique Wychem, Industrie Pharma, janvier, 2013.
  4. ^ [3], Isochem renforce son offre en chimie fine et s'implante en Grande-Bretagne, Usine Nouvelle, juillet, 2013.
  5. ^ Growing challenges of API process development in custom manufacturing, Chimica Oggi / Chemistry Today, 27, n°5, september-october, 2009.
  6. ^ Hydrogenation the key?, Specialty Chemicals Magazine, juin, 2009.
  7. ^ Phosgene Futures, Specialty Chemicals Magazine, November, 2011.
  8. ^ [4], Controlled Ring Opening of N-Sulfinyl- and N-Silyl-N-Carboxyanhydrides (NCA), Synlett, 2009 (2), 279-283.
  9. ^ Amino-Acid N-CarboxyAnhydrides: Industrial solutions for a growing demand, Specialty Chemicals Magazine, 28, n°5, june, 2008.
  10. ^ Peptide synthesis and Fine Chemistry merging for progress, PharmaChem, novembre-december, 2004
  11. ^ UNCAs - Focus on peptides & Amino-acids, Chimica Oggi / Chemistry Today, 23, n°3, june, 2005.
  12. ^ La Société Isochem à la pointe du traitement des déchets, Le Courrier du Loiret, n°3439, 29 novembre 2012
  13. ^ Isochem vise l'autonomie totale - Traitement des rejets, La République - Pithiviers, 29 novembre 2012.
  14. ^ [5], Phosgene-triphosgene: different approach in risk management?, Chimica Oggi / Chemistry Today, 29, n°4, july-august, 2011.

External links[edit]