Isoconazole

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Isoconazole
Isoconazole.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.084 Edit this at Wikidata
Chemical and physical data
FormulaC18H14Cl4N2O
Molar mass416.127 g/mol g·mol−1
3D model (JSmol)

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]

It was patented in 1968 and approved for medical use in 1979.[5]

References[edit]

  1. ^ a b Veraldi, Stefano (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 Suppl 1: 3–15. doi:10.1111/myc.12054. ISSN 1439-0507. PMID 23574019.
  2. ^ The Merck Index, 12th Edition, 5176
  3. ^ Oyeka, C.A.; Gugnani H.C. (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–61. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.
  4. ^ Cohen, L. (1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". Retrieved 2008-05-23.
  5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 502. ISBN 9783527607495.