Isoconazole

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Isoconazole
Isoconazole.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.044.084
Chemical and physical data
Formula C18H14Cl4N2O
Molar mass 416.127 g/mol
3D model (JSmol)

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]

References[edit]

  1. ^ a b Veraldi, Stefano (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 Suppl 1: 3–15. ISSN 1439-0507. PMID 23574019. doi:10.1111/myc.12054. 
  2. ^ The Merck Index, 12th Edition, 5176
  3. ^ Oyeka, C.A.; Gugnani H.C. (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.". Mycoses. 35 (11-12): 357–61. PMID 1302811. doi:10.1111/j.1439-0507.1992.tb00894.x. 
  4. ^ Cohen, L. (1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole.". Retrieved 2008-05-23.