Isopropyl myristate

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Isopropyl myristate[1]
Isopropyl myristate
Names
Preferred IUPAC name
Propan-2-yl tetradecanoate
Other names
Tetradecanoic acid, 1-methylethyl ester
Myristic acid isopropyl ester
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.003.412 Edit this at Wikidata
EC Number
  • 203-751-4
KEGG
MeSH C008205
RTECS number
  • XB8600000
UNII
  • InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 ☒N
    Key: AXISYYRBXTVTFY-UHFFFAOYSA-N ☒N
  • InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
    Key: AXISYYRBXTVTFY-UHFFFAOYAN
  • CCCCCCCCCCCCCC(=O)OC(C)C
Properties
C17H34O2
Molar mass 270.457 g·mol−1
Density 0.85 g/cm³
Boiling point 167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases (outdated) R38
S-phrases (outdated) S24/25
NFPA 704 (fire diamond)
0
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid.

Uses[edit]

Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.[2] It is used in the same way in flea and tick killing products for pets.

It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.

Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.[3][4]

References[edit]

  1. ^ MSDS for isopropyl myristate
  2. ^ Anti-Lice Treatments
  3. ^ Wen, Z.; Fang, L. and He, Z. (2009). Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Deliv, 16: 214-223
  4. ^ Engelbrecht, T.; Demé, B.; Dobner, B. and Neubert, R. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7

External links[edit]

  • Record in the Household Products Database of NLM