Isopropyl nitrite

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Isopropyl nitrite
Isopropyl nitrite 3d structure.png
Clinical data
Synonyms Isopropyl alcohol nitrite; nitrous acid, isopropyl ester; 1-methylethyl nitrite; 2-propyl nitrite
ATC code
  • None
CAS Number
PubChem CID
ECHA InfoCard 100.007.982 Edit this at Wikidata
Chemical and physical data
Formula C3H7NO2
Molar mass 89.09
3D model (JSmol)
Density 0.8684 g/cm3
Boiling point 40 °C (104 °F)

The chemical compound isopropyl nitrite (or 2-propyl nitrite) is an alkyl nitrite made from isopropanol. It is a clear pale yellow oil.[1]


Isopropyl nitrite is one of the compounds used as poppers, an inhalant drug that induces a brief euphoria. Isopropyl nitrite has largely replaced Isobutyl nitrite in poppers.


Isopropyl nitrite has been associated with eye maculopathy, visual impairment with central scotomata, bilateral foveal yellow spots, and inner segment/outer segment (IS/OS) junction disruption,[2] which may be reversible.[3]

The compound may also be potentially harmful to human body - inhaling isopropyl nitrite [and other alkyl nitrites] vapor could lead to headache and extremely low blood pressure as well as increased body temperature, even death.


  1. ^ Handbook of Chemistry and Physics, CRC Press, 85th edition
  2. ^ Davies, AJ; Kelly, SP; Naylor, SG; Bhatt, PR; Mathews, JP; Sahni, J; Haslett, R; McKibbin, M (2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye (Lond). 26: 1479–86. doi:10.1038/eye.2012.191. PMC 3496104Freely accessible. PMID 23079752. 
  3. ^ Inserm. "Des pertes visuelles chez les consommateurs de poppers". (in French). Retrieved 2017-01-23.