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|Systematic (IUPAC) name|
|Bioavailability||10–90%, average 25%|
|Biological half-life||1 hour|
|ATC code||C01 C05|
|Molecular mass||236.136 g/mol|
|(what is this?)|
Isosorbide dinitrate is sold in the USA under the brand names Dilatrate-SR by Schwarz and Isordil by Valeant, according to FDA Orange Book. In the United Kingdom, Argentina, and Hong Kong, a trade name of it is Isoket. It is also a component of BiDil. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
It is used for angina, in addition to other medications for congestive heart failure, and for esophageal spasms.
Long-acting nitrates can be more useful as they are generally more effective and stable in the short term.
After long-term use for treating chronic conditions, tolerance may develop in patients, reducing its effectiveness. The mechanisms of nitrate tolerance have been thoroughly investigated in the last 30 years and several hypotheses have been proposed. These include:
- Impaired biotransformation of ISDN to its active principle NO (or a NO-related species)
- Neurohormonal activation, causing sympathetic activation and release of vasoconstrictors such as endothelin and angiotensin II which counteract the vasodilation induced by ISDN
- Plasma volume expansion
- The oxidative stress hypothesis (proposed by Munzel et al. in 1995)
The last hypothesis might represent a unifying hypothesis, and an ISDN-induced inappropriate production of oxygen free radicals might induce a number of abnormalities which include the ones described above. Furthermore, nitrate tolerance is shown to be associated with vascular abnormalities which have the potential to worsen patients prognosis:  these include endothelial and autonomic dysfunction.  In the short run, ISDN can cause severe headaches, necessitating analgesic (very rarely up to morphine) administration for relief of pain, as well as severe hypotension, and, in certain cases, bradycardia. This makes some physicians nervous and should prompt caution when starting nitrate administration.
- "Isosorbide Dinitrate/Mononitrate". The American Society of Health-System Pharmacists. Retrieved Apr 21, 2014.
- "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- (Nakamura et al.)
- (Gori et al.).
- Goldberg, L. (1948). "Pharmacological Properties of Sorbide Dinitrate". Acta Physiologica Scandinavica 15 (2): 173–87. doi:10.1111/j.1748-1716.1948.tb00494.x. PMID 18863140.
- Pharmacol Exp Ther October 1939 67:187-190.