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Isotope effect can refer to:
- Equilibrium isotope effect: see Equilibrium constant#Effect of isotopic substitution
- Isotopic shift: effect of isotopic substitution on spectroscopy
- Kinetic isotope effect: effect of isotopic substitution on chemical reaction rates
- Magnetic isotope effect
- Superconductive transition temperature varying by isotope atomic weight: see BCS theory#Successes of the BCS theory
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