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Isovaleryl coenzyme A.svg
3D model (JSmol)
MeSH isovaleryl-coenzyme+A
Molar mass 851.652 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Isovaleryl-coenzyme A is an intermediate in branched-chain amino acids metabolism.

Metabolism in humans[edit]

Human metabolic pathway for β-hydroxy β-methylbutyric acid (HMB) and isovaleryl-CoA, relative to leucine.[1] Of the two major pathways, leucine is mostly metabolized into isovaleryl-CoA, while only 5% or so is metabolized into HMB.[1]

See also[edit]


  1. ^ a b Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR, Ziegenfuss TN, Lopez HL, Kreider RB, Smith-Ryan AE, Antonio J (February 2013). "International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)". J. Int. Soc. Sports. Nutr. 10 (1): 6. PMC 3568064Freely accessible. PMID 23374455. doi:10.1186/1550-2783-10-6.