3D model (Jmol)
|Molar mass||69.06202 g/mol|
|Boiling point||95 °C (203 °F; 368 K)|
|Acidity (pKa)||-3.0 (of conjugate acid) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Isoxazole is an azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. Isoxazolyl is the univalent radical derived from isoxazole.
Isoxazole rings are found in some natural products, such as ibotenic acid. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. A derivative, furoxan, is a nitric oxide donor.
The synthetic androgenic steroid danazol also has an isoxazole ring.
- Oxazole, an analog with the nitrogen atom in position 3.
- Pyrrole, an analog without the oxygen atom.
- Furan, an analog without the nitrogen atom.
- Simple aromatic rings
- Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978).