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Istros may refer to:


  • Histria (Sinoe) or Istros, an ancient Greek colony on the western shore of the Black Sea, near the modern village of Istria, Romania
  • The ancient Greek name for the lower section of the Danube, Europe's second longest river
  • In Greek mythology, one of the Potamoi (river gods), descended from the Titans Oceanus and Tethys, associated with the Istros River (modern Danube).