In 2015, Howard and Henson competed against each other the Season 1 finale of the Spike series Lip Sync Battle and, by popular demand, performed the song as the first duet by competitors in the show's history.
At the 78th Academy Awards in 2006, Three 6 Mafia and Henson performed the song shortly before it won the Academy Award for Best Original Song. Howard did not wish to perform at the ceremony, and since two of the song's writers are themselves artists in the form of the trio Three 6 Mafia, they were given the opportunity to perform it. In the live performance, the word "bitches" was replaced by "witches" in the chorus. Three 6 Mafia became the first hip hop group to win an Academy Award for Best Original Song, and the first hip hop artists to perform at the ceremony. It was the second hip hop song to win an Oscar, after Eminem's "Lose Yourself", from the film 8 Mile (2002).