Itapecerica da Serra is a municipality in the state of São Paulo in Brazil. It is part of the Metropolitan Region of São Paulo. The population is 167,236 (2015 est.) in an area of 150.74 km². It is located 23 miles southwest of São Paulo and at an altitude of 920m above sea level. The name Itapecerica is believed to come from the Tupi language for slippery stone, and da Serra means of the Mountains in Portuguese.