Itolizumab

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Itolizumab
Monoclonal antibody
Type Whole antibody
Source Humanized
Target CD6
Clinical data
Trade names Alzumab
ATC code
  • none
Legal status
Legal status
  • Approved in India
Identifiers
CAS Number
ChemSpider
  • none
UNII
 ☒N☑Y (what is this?)  (verify)

Itolizumab (INN, trade name Alzumab) is a ‘first in class’ humanized IgG1 monoclonal antibody developed by Biocon.[1] It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. Itolizumab, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation.[2] A double blind, placebo controlled, phase III treat –Plaq study of itolizumab successfully met the pre-specified primary end-point of significant improvement in PASI-75 (Psoriasis Area and Severity Index) score after 12 weeks of treatment in patients with moderate to severe psoriasis compared to placebo.[3] Biocon received marketing authorization for the drug from the Drugs Controller General of India (DCGI) in January 2013 and marketing within India commenced in August 2013.[1][4]

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