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Jagged 2
Symbols JAG2 ; HJ2; SER2
External IDs OMIM602570 MGI1098270 HomoloGene1677 GeneCards: JAG2 Gene
RNA expression pattern
PBB GE JAG2 32137 at tn.png
PBB GE JAG2 209784 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3714 16450
Ensembl ENSG00000184916 ENSMUSG00000002799
UniProt Q9Y219 Q9QYE5
RefSeq (mRNA) NM_002226 NM_010588
RefSeq (protein) NP_002217 NP_034718
Location (UCSC) Chr 14:
105.14 – 105.17 Mb
Chr 12:
112.91 – 112.93 Mb
PubMed search [1] [2]

Protein jagged-2 is a protein that in humans is encoded by the JAG2 gene.[1][2][3]


The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.[3]


JAG2 has been shown to interact with NOTCH2.[4]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.[5]


  1. ^ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol 17 (10): 6057–67. PMC 232455. PMID 9315665. 
  2. ^ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552. 
  3. ^ a b "Entrez Gene: JAG2 jagged 2". 
  4. ^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687. 
  5. ^ Wang, Remke, Bhat, Wong, Zhou, Ramaswamy, Dubuc, Fonkem, Salem, Zhang, Hsieh, O'Rourke, Wu, Li, Hawkins, Kohane, Wu, Wu, Taylor, Wu (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel bilogical target in high-risk medulloblastoma". Oncotarget 6: 2709–24. doi:10.18632/oncotarget.2779. PMID 25576913. 

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