JAG2

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JAG2
Identifiers
AliasesJAG2, HJ2, SER2, jagged 2, jagged canonical Notch ligand 2
External IDsOMIM: 602570 MGI: 1098270 HomoloGene: 1677 GeneCards: JAG2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for JAG2
Genomic location for JAG2
Band14q32.33Start105,140,982 bp[1]
End105,168,824 bp[1]
RNA expression pattern
PBB GE JAG2 32137 at fs.png

PBB GE JAG2 209784 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002226
NM_145159

NM_010588

RefSeq (protein)

NP_002217
NP_660142

NP_034718

Location (UCSC)Chr 14: 105.14 – 105.17 MbChr 12: 112.91 – 112.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.[5][6][7]

Function[edit]

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions[edit]

JAG2 has been shown to interact with NOTCH2.[8]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184916 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002799 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. PMC 232455. PMID 9315665.
  6. ^ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
  7. ^ a b "Entrez Gene: JAG2 jagged 2".
  8. ^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
  9. ^ Wang; Remke; Bhat; Wong; Zhou; Ramaswamy; Dubuc; Fonkem; Salem; Zhang; Hsieh; O'Rourke; Wu; Li; Hawkins; Kohane; Wu; Wu; Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma". Oncotarget. 6: 2709–24. doi:10.18632/oncotarget.2779. PMC 4413612. PMID 25576913.

Further reading[edit]