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Junctional adhesion molecule 2
Symbols JAM2 ; C21orf43; CD322; JAM-B; JAMB; PRO245; VE-JAM; VEJAM
External IDs OMIM606870 MGI1933820 HomoloGene10929 GeneCards: JAM2 Gene
RNA expression pattern
PBB GE JAM2 219213 at tn.png
More reference expression data
Species Human Mouse
Entrez 58494 67374
Ensembl ENSG00000154721 ENSMUSG00000053062
UniProt P57087 Q9JI59
RefSeq (mRNA) NM_001270407 NM_023844
RefSeq (protein) NP_001257336 NP_076333
Location (UCSC) Chr 21:
25.64 – 25.72 Mb
Chr 16:
84.77 – 84.83 Mb
PubMed search [1] [2]

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[1][2][3] JAM2 has also been designated as CD322 (cluster of differentiation 322).


Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[3]

It is purported to promote lymphocyte transendothelial migration.[4] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PAR-3, together with JAM3.[5]


JAM2 has been shown to interact with PARD3.[5]

It also interacts with α4β1.[6]


  1. ^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem 275 (25): 19139–45. doi:10.1074/jbc.M003189200. PMID 10779521. 
  2. ^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem 275 (44): 34750–6. doi:10.1074/jbc.M002718200. PMID 10945976. 
  3. ^ a b "Entrez Gene: JAM2 junctional adhesion molecule 2". 
  4. ^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood 100 (7): 2479–86. doi:10.1182/blood-2001-11-0098. PMID 12239159. 
  5. ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell. Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056. 
  6. ^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.