KDM4A

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KDM4A
Protein JMJD2A PDB 2gf7.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A, lysine demethylase 4A
External IDsMGI: 2446210 HomoloGene: 27780 GeneCards: KDM4A
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KDM4A
Genomic location for KDM4A
Band1p34.2-p34.1Start43,650,158 bp[1]
End43,705,515 bp[1]
RNA expression pattern
PBB GE JMJD2A 203205 at fs.png

PBB GE JMJD2A 203204 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014663

NM_001161823
NM_172382

RefSeq (protein)

NP_055478

NP_001155295
NP_759014

Location (UCSC)Chr 1: 43.65 – 43.71 MbChr 4: 118.14 – 118.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene.[5][6][7]

Function[edit]

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone on histone H3 lysine 9 and 36 residues to the dimethylated form and lysine 9 dimethylated residues to monomethyl, and as a transcriptional repressor.[7]

Alterations in this gene have been found associated with chromosomal instability that leads to cancer.(PMID 23871696)

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066135 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033326 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  6. ^ Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608. 
  7. ^ a b "Entrez Gene: JMJD2A jumonji domain containing 2A". 

Further reading[edit]