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JT010 structure.png
Preferred IUPAC name
3D model (JSmol)
  • InChI=1S/C16H19ClN2O3S/c1-21-9-3-8-19(15(20)10-17)16-18-14(11-23-16)12-4-6-13(22-2)7-5-12/h4-7,11H,3,8-10H2,1-2H3
  • O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
Molar mass 354.85 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

JT-010 is a chemical compound which acts as a potent, selective activator of the TRPA1 channel, and has been used to study the role of this receptor in the perception of pain, as well as other actions such as promoting repair of dental tissue after damage.[1][2][3][4]

See also[edit]


  1. ^ Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M (December 2015). "A Potent and Site-Selective Agonist of TRPA1". Journal of the American Chemical Society. 137 (50): 15859–64. doi:10.1021/jacs.5b10162. hdl:2433/215437. PMID 26630251.
  2. ^ Heber S, Gold-Binder M, Ciotu CI, Witek M, Ninidze N, Kress HG, Fischer MJ (May 2019). "A Human TRPA1-Specific Pain Model". The Journal of Neuroscience. 39 (20): 3845–3855. doi:10.1523/JNEUROSCI.3048-18.2019. PMC 6520506. PMID 30862667.
  3. ^ Suo Y, Wang Z, Zubcevic L, Hsu AL, He Q, Borgnia MJ, et al. (March 2020). "Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel". Neuron. 105 (5): 882–894.e5. doi:10.1016/j.neuron.2019.11.023. PMC 7205012. PMID 31866091.
  4. ^ Tazawa K, Kawashima N, Kuramoto M, Noda S, Fujii M, Nara K, et al. (September 2020). "Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization". The American Journal of Pathology. 190 (12): 2417–2426. doi:10.1016/j.ajpath.2020.08.016. PMID 32919979. S2CID 221674768.