Jumping translocation breakpoint

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JTB
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases JTB, HHSPC222, PAR, hJT, jumping translocation breakpoint
External IDs MGI: 1346082 HomoloGene: 4870 GeneCards: JTB
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for JTB
Genomic location for JTB
Band 1q21.3 Start 153,974,269 bp[1]
End 153,977,688 bp[1]
RNA expression pattern
PBB GE JTB 210434 x at fs.png

PBB GE JTB 210927 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006694

NM_206924

RefSeq (protein)

NP_006685

NP_996807

Location (UCSC) Chr 1: 153.97 – 153.98 Mb Chr 1: 90.23 – 90.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
Jumping translocation breakpoint protein (JTB)
Identifiers
Symbol JTB
Pfam PF05439
InterPro IPR008657

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.[5][6] It is an orphan receptor with unknown function.[7]

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).[5] JTB has also been implicated in prostatic carcinomas.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143543 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027937 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Hatakeyama S, Osawa M, Omine M, Ishikawa F (Jun 1999). "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene. 18 (12): 2085–90. doi:10.1038/sj.onc.1202510. PMID 10321732. 
  6. ^ "Entrez Gene: JTB jumping translocation breakpoint". 
  7. ^ Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology. 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049. 
  8. ^ Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M (May 2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR008657