JUB (gene)

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AJUBA
Identifiers
Aliases AJUBA, JUB, ajuba LIM protein
External IDs MGI: 1341886 HomoloGene: 7789 GeneCards: AJUBA
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198086
NM_001289097
NM_032876

NM_010590

RefSeq (protein)

NP_001276026
NP_116265
NP_932352

NP_034720.2
NP_034720

Location (UCSC) Chr 14: 22.97 – 22.98 Mb Chr 14: 54.57 – 54.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein ajuba is a protein that in humans is encoded by the JUB gene.[3][4]

Function[edit]

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions[edit]

JUB (gene) has been shown to interact with Stratifin[5] and SLC1A2.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol. 19 (6): 4379–89. PMC 104397Freely accessible. PMID 10330178. 
  4. ^ "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)". 
  5. ^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
  6. ^ Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269. 

Further reading[edit]