JWH-047

JWH-047
Identifiers
	IUPAC name (1-butyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone;
CAS Number	316189-65-8;
ChemSpider	35303438;
Chemical and physical data
Formula	C25H25NO
Molar mass	355.47 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCn1c(c(c2c1cccc2)C(=O)c3cccc4c3cc(cc4)C)C;
	InChI InChI=1S/C25H25NO/c1-4-5-15-26-18(3)24(21-10-6-7-12-23(21)26)25(27)20-11-8-9-19-14-13-17(2)16-22(19)20/h6-14,16H,4-5,15H2,1-3H3; Key:RQWLYQGWFKBOIY-UHFFFAOYSA-N;

JWH-047 is a selective cannabinoid ligand, with a bindining affinity of K_i = 0.9 nM for the CB₂ subtype, and more than 65 times selectivity over the CB₁.^[1]

References

^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540. {{cite journal}}: Cite has empty unknown parameter: |month= (help)

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[Aung_2000-1] Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540. {{cite journal}}: Cite has empty unknown parameter: |month= (help)

[1]

See also

References