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Systematic (IUPAC) name
Clinical data
Legal status
CAS Number 619294-47-2 N
ChemSpider 24623066 YesY
Chemical data
Formula C25H25NO
Molecular mass 355.472 g/mol
 N (what is this?)  (verify)

JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.[1]

In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, CA that was laced with JWH-122.[2]

Legal Status[edit]

As of October 2015 JWH-122 is a controlled substance in China.[3]

See also[edit]


  1. ^ Huffman, J.; et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455. 
  2. ^ http://www.foodsafetynews.com/2015/02/tests-show-synthetic-drug-contaminated-holiday-bread-from-ca-bakery/
  3. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.