Jacqueline Crawley

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Jacqueline N. Crawley
JackiCrawley.jpg
NationalityUnited States
Alma materUniversity of Pennsylvania
Known forWhat's Wrong with my Mouse
AwardsMarjorie A. Myers Lifetime Achievement Award (International Behavioral Neuroscience Society), Distinguished Scientist Award (International Behavioural and Neural Genetics Society)
Scientific career
FieldsBehavior genetics, behavioral neuroscience, behavioral pharmacology
InstitutionsNational Institute of Mental Health, University of California, Davis
Doctoral advisorWolfgang Schleidt, Joseph Contrera

Jacqueline N. Crawley (née Lerner) is an American behavioral neuroscientist and an expert on rodent behavioral analysis.[1] Since July 2012, she is the Robert E. Chason Chair in Translational Research at the University of California, Davis School of Medicine and the UC Davis MIND Institute.[2] Previously, from 1983-2012, she was chief of the Laboratory of Behavioral Neuroscience in the intramural program of the National Institute of Mental Health.[3][2] Her translational research program focuses on testing hypotheses about the genetic causes of autism spectrum disorders and discovering treatments for the diagnostic symptoms of autism, using mouse models.[3] She has published more than 260 peer-reviewed articles in scientific journals and over 100 review articles and book chapters. According to the Web of Science, her works have been cited over 16,000 times, giving her an h-index of 72.[4] She has co-edited 4 books and is the author of What's Wrong With my Mouse (2nd edition, ISBN 978-0-471-47192-9), which was very well received.[5][6][7][8]

Education[edit]

Crawley obtained her B.A. in biology from the University of Pennsylvania in 1971 and her PhD in 1976 from the University of Maryland, College Park. She then did postdoctoral research in neuropsychopharmacology at the Yale School of Medicine (1976-1979).[9]

Behavioral test development[edit]

Crawley is at the origin of several widely employed tests used to evaluate, for example, anxiety-related and social behavior in rodents, especially mice. Early in her career, she developed the dark-light mouse exploration test, and showed that it is a valid test for anxiety-like behaviors.[10][11][12] More recently, she developed the three-compartment test to evaluate mouse social behavior.[13][14][15][16]

Honors[edit]

Crawley has been president of the International Behavioral Neuroscience Society (2000-2001)[17] and the International Behavioural and Neural Genetics Society (2008-2011).[18] She has been editor-in-chief of Neuropeptides and serves on several editorial boards, among them Autism Research,[19] Genes, Brain and Behavior,[20] and Trends in Pharmacological Sciences. In 2011, Crawley received the IBANGS Distinguished Investigator Award, which "recognizes the contributions of a senior scientist to the field, considering research, mentorship, and continued impact on the field".[21]

References[edit]

  1. ^ Tsao, J. (2008). "J. Crawley, What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, Wiley-Interscience, Hoboken, NJ (2007) 523 pages, $99.95". Journal of the Neurological Sciences. 267: 190. doi:10.1016/j.jns.2007.09.031.
  2. ^ a b "Internationally renowned neuroscientist joins UC Davis MIND Institute". University of California, Davis. Retrieved 2012-09-19.
  3. ^ a b NIMH Division of Intramural Research Programs: Jacqueline N. Crawley, Ph.D. Archived May 27, 2010, at the Wayback Machine
  4. ^ "Web of Science". 2011. Retrieved 2011-05-30.
  5. ^ Wolfer, D. P. (2002). "J.N. Crawley: What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice". Genes, Brain and Behavior. 1 (2): 131. doi:10.1034/j.1601-183X.2002.102081.x.
  6. ^ Crusio, W. E. (2008). "J.N. Crawley: What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice". Genes, Brain and Behavior. 7 (7): 831. doi:10.1111/j.1601-183X.2008.00424_1.x.
  7. ^ Belknap, J. K. (2001). "Behavioral screening of mutant mice". Trends in Neurosciences. 24 (5): 301–302. doi:10.1016/S0166-2236(00)01736-7.
  8. ^ Gerlai, R. (2000). "A guide to good behavior". Nature Neuroscience. 3 (12): 1240. doi:10.1038/81764. PMID 11100143.
  9. ^ "Curriculum Vitae Jacqueline N. Crawley" (PDF). Retrieved 2011-05-31.
  10. ^ Crawley, J.; Goodwin, F. (1980). "Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines". Pharmacology Biochemistry and Behavior. 13 (2): 167–170. doi:10.1016/0091-3057(80)90067-2. PMID 6106204.
  11. ^ Blumstein, L.; Crawley, J. (1983). "Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines". Pharmacology Biochemistry and Behavior. 18 (1): 37–40. doi:10.1016/0091-3057(83)90247-2. PMID 6828535.
  12. ^ Crawley, J.; Davis, L. (1982). "Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains". Brain Research Bulletin. 8 (6): 609–612. doi:10.1016/0361-9230(82)90087-9. PMID 6890398.
  13. ^ Crawley, J. N. (2004). "Designing mouse behavioral tasks relevant to autistic-like behaviors". Mental Retardation and Developmental Disabilities Research Reviews. 10 (4): 248–258. doi:10.1002/mrdd.20039. PMID 15666335.
  14. ^ Moy, S. S.; Nadler, J. J.; Perez, A.; Barbaro, R. P.; Johns, J. M.; Magnuson, T. R.; Piven, J.; Crawley, J. N. (2004). "Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice". Genes, Brain and Behavior. 3 (5): 287–302. doi:10.1111/j.1601-1848.2004.00076.x. PMID 15344922.
  15. ^ Nadler, J. J.; Moy, S. S.; Dold, G.; Simmons, N.; Perez, A.; Young, N. B.; Barbaro, R. P.; Piven, J.; Magnuson, T. R.; Crawley, J. N.; Crawley, J. N. (2004). "Automated apparatus for quantitation of social approach behaviors in mice". Genes, Brain and Behavior. 3 (5): 303–314. doi:10.1111/j.1601-183X.2004.00071.x. PMID 15344923.
  16. ^ Crawley, J. N. (2007). "Mouse Behavioral Assays Relevant to the Symptoms of Autism". Brain Pathology. 17 (4): 448–459. doi:10.1111/j.1750-3639.2007.00096.x. PMID 17919130.
  17. ^ "IBNS Past Presidents". Homepage. International Behavioral Neuroscience Society. Retrieved 2011-05-30.
  18. ^ "Past Officers and Members of the Executive Committees". Homepage. International Behavioural and Neural Genetics Society. Retrieved 2011-05-30.
  19. ^ "Autism Research - Editorial Board". Autism Research. doi:10.1002/(ISSN)1939-3806.
  20. ^ "Genes, Brain and Behavior - Journal Information". Wiley-Blackwell. Retrieved 2011-05-30.
  21. ^ "IBANGS Awards". Homepage. International Behavioural and Neural Genetics Society. Retrieved 2011-05-30.

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