James or Jim Blake may refer to:
- James Blake (musician) (born 1988), British electronic music producer and singer-songwriter
- James Blake (tennis) (born 1979), American professional tennis player
- James Carlos Blake (born 1947), writer, winner of Los Angeles Times Book Prize for fiction, 1997
- James F. Blake (1912–2002), American bus driver defied by Rosa Parks
- James H. Blake (1768–1819), American politician, mayor of Washington, D.C.
- James Henry Blake (1808–1874), Boston Police Marshal in 1840
- James J. Blake, American diplomat, United States Ambassador to Iceland
- James "Spanish" Blake (died 1635), Irish Nine Years' War figure
- James Vila Blake (1842–1925), American Unitarian minister, essayist, playwright and hymn writer and poet
- Eubie Blake (James Hubert Blake, 1887–1983), American musician
- Jim Blake (Australian politician) (1921–2010), member of the Queensland Legislative Assembly
- Ronald James Blake (born 1934), aka James Blake, British civil engineer in Hong Kong, CEO of KCRC
Arts, entertainment, and media
- James Blake (album), self-titled debut album of the musician
- Jim Blake, character in the film Across the Plains (1928)
- James Blake House, oldest house in Boston, USA
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