James Bryce may refer to:
- James Bryce (Belfast) (1806–1877), Irish naturalist and geologist
- James Bryce (footballer) (1891–1915), Scottish footballer
- James Bryce, 1st Viscount Bryce (1838–1922), British jurist, historian and politician
- James W. Bryce (1880–1949), North American inventor and pioneer in magnetic data recording
- James Bryce (surgeon) FRSE (1766–1826), President of the Royal College of Surgeons of Edinburgh 1816, President of the Harveian Society 1802.
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