James L. Gulley

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James L. Gulley
EducationLoma Linda University, Emory University, National Cancer Institute
Medical career
ProfessionMedical oncologist
InstitutionsNational Cancer Institute
Sub-specialtiesgenitourinary oncology, immunotherapy
Researchcancer research
Website

James L. Gulley is an American cancer researcher and the Director of the Medical Oncology Service at National Cancer Institute.[1]

Early Life & Education[edit]

He graduated from Loma Linda University, California[2] and his M.D./Ph.D. Medical Scientist Training Program, at National Institutes of Health (NIH) and his dissertation on tumor immunology.[3]

Later, Dr. Gulley did his residency in internal medicine at Emory University in 1998, followed by a medical oncology fellowship at the NCI.[4]

Research & Career[edit]

Dr. Gulley did his research in immunotherapy for prostate cancer. His studies involved the use of cancer vaccine[5] and immune checkpoint inhibitors or other strategies to enhance vaccine-mediated killing.[6]

Since 1999, he ran a variety of clinical trials at the NCI[7], serving as Principal Investigator or an Associate Investigator on approximately 40 trials. He is also running several studies on cancer patients.[8][9][10]

Publications[edit]

He published over 250 research papers & book chapters across leading journals.[11][12] Some of his notable publications are listed below:

  • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer[13]
  • Androgen deprivation therapy for prostate cancer[14]
  • Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer[15]
  • Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer[16]
  • Phase I study of sequential vaccinations with fowlpox-CEA (6D)-TRICOM alone and sequentially with vaccinia-CEA (6D)-TRICOM[17]
  • A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.[18]
  • Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer[19]
  • Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial[20]

FDA Approval[edit]

At the 2010 ASCO meeting Dr. Gulley and his group reported on the use of Ipilimumab with a vector-based vaccine for treating advanced prostate cancer. This phase I trial using PSA-TRICOM with Ipilimumab (Ipi) showed promise for Overall Survival (OS).[21] Ipi is used in melanoma vaccine clinical trials.[22] It was approved by the FDA in March 2011.[23][24][25][26]

Awards[edit]

  • He received Presidential Early Career Award for Science and Engineering “For randomized, controlled studies using novel, recombinant vaccines to reduce the progression of prostate and other cancers and increase survival.” [27][28]
  • He received Federal Laboratory Consortium Excellence in Federal Technology Transfer Award, a national award for “Development of first immunotherapy to treat chordoma, a rare bone cancer.”[29]

References[edit]

  1. ^ "Medical Oncology Service". Center for Cancer Research. 2016-02-09. Retrieved 2019-08-22.
  2. ^ "James L. Gulley, M.D., Ph.D." Center for Cancer Research. 2014-08-12. Retrieved 2019-11-16.
  3. ^ "Principal Investigators". NIH Intramural Research Program. Retrieved 2019-08-06.
  4. ^ "Medical Oncology Web - FELLOWSHIP". Medicaloncology.cancer.gov. Retrieved 2010-07-14.
  5. ^ Gulley, James L.; Arlen, Philip M.; Schlom, Jeffrey (2007-07-01). "Cancer Vaccines: Moving Beyond Current Paradigms". Clinical Cancer Research. 13 (13): 3776–3782. doi:10.1158/1078-0432.CCR-07-0588. ISSN 1078-0432. PMC 2536755. PMID 17606707.
  6. ^ "James L. Gulley, MD, PhD, on Prostate Cancer: Expanding Immunotherapy Options - The ASCO Post". ascopost.com. Retrieved 2019-08-22.
  7. ^ Gulley, James (2015-02-23). "James Gulley". NIH Intramural Research Program. Retrieved 2019-11-16.
  8. ^ "Clinical Trials at NIH: Health Care Professionals: Investigator Profiles: James L. Gulley, M.D". Bethesdatrials.cancer.gov. Archived from the original on 2010-05-27. Retrieved 2010-07-14.
  9. ^ "Clinical Trials at NIH: Health Care Professionals: Investigator Profiles: James L. Gulley, M.D." web.archive.org. 2010-05-27. Retrieved 2019-08-22.
  10. ^ "Genitourinary Malignancies Branch Clinical Trials". Center for Cancer Research. Retrieved 2019-08-22.
  11. ^ "My Bibliography James Gulley's Bibliography".
  12. ^ "Center for Cancer Research - Staff Pages". Ccr.cancer.gov. Archived from the original on 2010-05-27. Retrieved 2010-07-14.
  13. ^ Kantoff, Philip W.; Schuetz, Thomas J.; Blumenstein, Brent A.; Glode, L. Michael; Bilhartz, David L.; Wyand, Michael; Manson, Kelledy; Panicali, Dennis L.; Laus, Reiner (2010-03-01). "Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer". Journal of Clinical Oncology. 28 (7): 1099–1105. doi:10.1200/JCO.2009.25.0597. ISSN 1527-7755. PMC 2834462. PMID 20100959.
  14. ^ Dahut, William L.; Gulley, James L.; Sharifi, Nima (2005-07-13). "Androgen Deprivation Therapy for Prostate Cancer". JAMA. 294 (2): 238–244. doi:10.1001/jama.294.2.238. ISSN 0098-7484. PMID 16014598.
  15. ^ Dahut, William L.; Gulley, James L.; Arlen, Philip M.; Liu, Yinong; Fedenko, Katherine M.; Steinberg, Seth M.; Wright, John J.; Parnes, Howard; Chen, Clara C. (2004-07-01). "Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer". Journal of Clinical Oncology. 22 (13): 2532–2539. doi:10.1200/JCO.2004.05.074. ISSN 0732-183X. PMID 15226321.
  16. ^ Gulley, James L.; Arlen, Philip M.; Bastian, Anne; Morin, Steven; Marte, Jennifer; Beetham, Patricia; Tsang, Kwong-Yok; Yokokawa, Junko; Hodge, James W. (2005-05-01). "Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer". Clinical Cancer Research. 11 (9): 3353–3362. doi:10.1158/1078-0432.CCR-04-2062. ISSN 1078-0432. PMID 15867235.
  17. ^ Marshall, John L.; Gulley, James L.; Arlen, Philip M.; Beetham, Patricia K.; Tsang, Kwong-Yok; Slack, Rebecca; Hodge, James W.; Doren, Sandra; Grosenbach, Douglas W. (2005-02-01). "Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas". Journal of Clinical Oncology. 23 (4): 720–731. doi:10.1200/JCO.2005.10.206. ISSN 0732-183X. PMID 15613691.
  18. ^ Arlen, Philip M.; Gulley, James L.; Parker, Catherine; Skarupa, Lisa; Pazdur, Mary; Panicali, Dennis; Beetham, Patricia; Tsang, Kwong Y.; Grosenbach, Douglas W. (2006-02-15). "A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer". Clinical Cancer Research. 12 (4): 1260–1269. doi:10.1158/1078-0432.CCR-05-2059. ISSN 1078-0432. PMC 1526707. PMID 16489082.
  19. ^ Gulley, James L.; Arlen, Philip M.; Madan, Ravi A.; Tsang, Kwong-Yok; Pazdur, Mary P.; Skarupa, Lisa; Jones, Jacquin L.; Poole, Diane J.; Higgins, Jack P. (2010). "Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer". Cancer Immunology, Immunotherapy. 59 (5): 663–674. doi:10.1007/s00262-009-0782-8. ISSN 1432-0851. PMC 2832083. PMID 19890632.
  20. ^ Madan, Ravi A.; Mohebtash, Mahsa; Arlen, Philip M.; Vergati, Matteo; Rauckhorst, Myrna; Steinberg, Seth M.; Tsang, Kwong Y.; Poole, Diane J.; Parnes, Howard L. (2012). "Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial". The Lancet. Oncology. 13 (5): 501–508. doi:10.1016/S1470-2045(12)70006-2. ISSN 1474-5488. PMC 6359905. PMID 22326924.
  21. ^ Madan, Ravi A.; Mohebtash, Mahsa; Arlen, Philip M.; Vergati, Matteo; Rauckhorst, Myrna; Steinberg, Seth M.; Tsang, Kwong Y.; Poole, Diane J.; Parnes, Howard L. (2012). "Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial". The Lancet. Oncology. 13 (5): 501–508. doi:10.1016/S1470-2045(12)70006-2. ISSN 1474-5488. PMC 6359905. PMID 22326924.
  22. ^ Sarnaik, A. A.; Yu, B.; Yu, D.; Morelli, D.; Hall, M.; Bogle, D.; Yan, L.; Targan, S.; et al. (2010). "Extended Dose Ipilimumab with a Peptide Vaccine: Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma". Clinical Cancer Research. 17 (4): 896–906. doi:10.1158/1078-0432.CCR-10-2463. PMC 3041838. PMID 21106722.
  23. ^ Hoos, Axel; Ibrahim, Ramy; Korman, Alan; Abdallah, Kald; Berman, David; Shahabi, Vafa; Chin, Kevin; Canetta, Renzo; Humphrey, Rachel (2010). "Development of Ipilimumab: Contribution to a New Paradigm for Cancer Immunotherapy". Seminars in Oncology. 37 (5): 533–46. doi:10.1053/j.seminoncol.2010.09.015. PMID 21074069.
  24. ^ http://www.cancer.gov/clinicaltrials/results/ipilimumab0610
  25. ^ Madan, Ravi A.; Mohebtash, Mahsa; Arlen, Philip M.; Vergati, Matteo; Rauckhorst, Myrna; Steinberg, Seth M.; Tsang, Kwong Y.; Poole, Diane J.; Parnes, Howard L. (2012). "Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial". The Lancet. Oncology. 13 (5): 501–508. doi:10.1016/S1470-2045(12)70006-2. ISSN 1474-5488. PMC 6359905. PMID 22326924.
  26. ^ Schlom, Jeffrey; Gulley, James L. (2018-12-04). "Vaccines as an Integral Component of Cancer Immunotherapy". JAMA. 320 (21): 2195–2196. doi:10.1001/jama.2018.9511. ISSN 1538-3598. PMC 6538063. PMID 30419097.
  27. ^ "President Obama Honors Outstanding Early-Career Scientists". whitehouse.gov. 2011-09-26. Retrieved 2019-08-22.
  28. ^ "CCR Connections (News) - An Early Career Off to a Stellar Start". home.ccr.cancer.gov. Retrieved 2019-08-22.
  29. ^ "Recent CCR Awards". Center for Cancer Research. 2016-06-21. Retrieved 2019-08-22.

External links[edit]