In the early 1880s, common crown and bridge techniques were not well known or widespread. Williams sought to make information on these techniques available to all dentists through the pages of The Dental Cosmos. In 1885, he embarked on a journey to improve the state of dental prostheses by designing more aesthetic artificial teeth that better matched the overall facial dimensions of the patient. He convinced an American artificial tooth manufacturer to take up his cause and produce his designs, on the condition that other dentists would embrace the new forms.
Williams also practiced dentistry in London and was one of the founders of the International Association for Dental Research.
He also was the author of The Home and Haunts of Shakespeare and had an interest in anthropology, including the Piltdown Man.