James Edward Rothman (born November 3, 1950) is an American biochemist. He is the Fergus F. Wallace Professor of Biomedical Sciences at Yale University, the Chairman of the Department of Cell Biology at Yale School of Medicine, and the Director of the Nanobiology Institute at the Yale West Campus. Rothman is also concurrently serving as adjunct professor of physiology and cellular biophysics at [4 ] Columbia University. and a research professor at the [5 ] Institute of Neurology, University College London (UCL). Rothman was awarded the 2013 [6 ] Nobel Prize in Physiology or Medicine, for his work on vesicle trafficking (shared with Randy Schekman and Thomas C. Südhof). He has also received many other honors, including the [7 ] King Faisal International Prize in 1996, the [8 ] Louisa Gross Horwitz Prize from Columbia University and the Albert Lasker Award for Basic Medical Research both in 2002. [9 ] [10 ]
Education [ edit ]
Rothman earned his high school diploma from
Pomfret School, then graduated from the ivy academia in 1967 then received his B.A. in physics at Yale University in 1971 and his Ph.D. in biological chemistry at Harvard in 1976 working with Eugene Patrick Kennedy. [11 ]
Career and research [ edit ]
Following his Phd, Rothman did
postdoctoral research with Harvey Lodish at Massachusetts Institute of Technology working on glycosylation of membrane proteins. [1 ] He moved to the Department of Biochemistry at [11 ] Stanford University in 1978. He was at Princeton University, from 1988 to 1991, before coming to New York to found the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center, where he also served as vice chairman of Sloan-Kettering Institute. In 2003, he left Sloan-Kettering to become a professor of physiology at Columbia University's College of Physicians and Surgeons and the head of Columbia's Center for Chemical Biology. He moved from Columbia to Yale in 2008, retaining a part-time appointment at Columbia. [12 ]
In 1995, Rothman joined the
Amersham plc scientific advisory board. When Amersham was acquired by GE Healthcare in 2003, Rothman was appointed as the Chief Science Advisor to GE Healthcare.
Nobel Prize Ceremony: James Rothman receives his award from king of Sweden.
details how vesicles—tiny sac-like structures that transport hormones, growth factors, and other molecules within cells—know how to reach their correct destination and where and when to release their contents. This cellular trafficking underlies many critical physiological functions, including the propagation of the cell itself in division, communication between nerve cells in the brain, secretion of insulin and other hormones in the body, and nutrient uptake. Defects in this process lead to a wide variety of conditions, including diabetes and infectious diseases such as [13 ] botulism.
Awards and honors [ edit ]
Rothman was awarded the 2010
Kavli Prize Neuroscience together with Richard Scheller and Thomas C. Südhof for "discovering the molecular basis of neurotransmitters release". [14 ]
Rothman was awarded the 2013
Nobel prize in Physiology or Medicine together with Randy Schekman and Thomas C. Südhof for “their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.” [15 ] [16 ] [17 ]
Rothman is a member of the
National Academy of Sciences and its Institute of Medicine. [11 ]
References [ edit ]
^ a b "James E. Rothman, Faculty: Yale Department of Chemistry". Chem.yale.edu . Retrieved . 2013-10-07
^ Miesenböck, G.; Rothman, J. E. (1997). "Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins". Proceedings of the National Academy of Sciences of the United States of America 94 (7): 3402–3407. doi: 10.1073/pnas.94.7.3402. PMC 20382. PMID 9096406.
^ Miesenböck, G.; De Angelis, D. A.; Rothman, J. E. (1998). "Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins". Nature 394 (6689): 192–195. doi: 10.1038/28190. PMID 9671304.
^ "James E Rothman" . Retrieved . 7 October 2013
^ "P&S Adjunct Faculty Member Wins 2013 Nobel Prize". Columbia Newsroom . Retrieved . 13 October 2013
^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation . Retrieved . October 7, 2013
^ "KFIP Winners Archive" (PDF). King Faisal Foundation.
^ Neill, Ushma S. (2015). "A conversation with James Rothman". Journal of Clinical Investigation 125 (2): 460–461. doi: 10.1172/JCI80641. ISSN 0021-9738. PMID 25642705.
^ Wickner, W. T. (2013). "Profile of Thomas Sudhof, James Rothman, and Randy Schekman, 2013 Nobel Laureates in Physiology or Medicine". Proceedings of the National Academy of Sciences 110 (46): 18349–18350. doi: 10.1073/pnas.1319309110. ISSN 0027-8424. PMC 3832004. PMID 24158482.
^ a b c "Yale’s James Rothman shares 2013 Nobel Prize in Physiology or Medicine". Yale News. 7 October 2013 . Retrieved . 7 October 2013
^ "Leading Cell Biologist Joins Columbia University College of Physicians & Surgeons". Columbia Medical Center Newsroom . Retrieved . 13 October 2013
^ James Rothman's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
^ "JAMES ROTHMAN". Kavlifoundation.org. 2010-09-06 . Retrieved . 2013-10-07
^ Altman, Lawrence (7 October 2013). "3 Win Joint Nobel Prize in Medicine". NY Times . Retrieved . 7 October 2013
^ "James E. Rothman, Ph.D. ’76, Shares Nobel Prize for Medicine". Harvard Magazine. 7 October 2013 . Retrieved . 7 October 2013
^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Prize . Retrieved . 7 October 2013