Scott is one of the main collaborators with UK boy band One Direction having written singles Story of My Life, Night Changes, You & I, Midnight Memories and More Than This. Scott co-wrote their fifth studio album Made in the A.M. released in November 2015. Its debut single Drag Me Down went straight in at No. 1 in the UK Singles Charts and debuted at No. 3 in the Billboard Hot 100 chart (their highest Billboard charting to date). The track went on to reach the number one spot on iTunes in 90 countries. Scott went on to co-write and produce called 'Home', taken from the boys' 'Perfect EP’ which has reached the number one spot on US iTunes.
Scott opened up for One Direction for 5 dates on their Where We Are Tour, playing 24 August 2014 and 27 August 2014 in Dallas and St. Louis as well as the 3 Rose Bowl shows in Pasadena, California.
Scott has also written and produced music under the name J.S. Baylin and was the writer and lead vocalist behind the band Jamie Scott and The Town. Scott relocated to Los Angeles in 2011 where he worked on an collaboration with TommyD called Graffiti6, they were signed to Capitol Records.
Scott's solo album "My Hurricane" was released on 20 January 2015 and debuted at #14 on the iTunes chart in America.
According to his website, Scott never listened to popular, contemporary music while he was growing up. Scott started his musical career by pursuing a publishing deal for music written for someone else to sing. When Jamie Scott sent his demo tape to publishers, they responded that they liked his voice and wanted him to sing the songs for himself. Because of this, Scott signed a contract with Sony Music in 2002. He then teamed up with producer Toby Smith, a former keyboardist from Jamiroquai, to work on his full-length album. As he was working on this album, Scott played solo shows with only his acoustic guitar. He then played a Blues & Soul magazine tour. Following that, he performed with artists such as Alicia Keys, Ryan Adams, Carleen Anderson, Gabrielle, Kelly Clarkson, Mario Winans, and Ginuwine.
Scott's full-length album, then titled Soul Searching, was scheduled to be out in early 2005. However, due to the merger between Sony and BMG, production got delayed. His song, "Made", is on the soundtrack to the motion picture Step Up. Scott performs the song in the film, and he also has a brief part as the character Colin. He also plays guitar while Drew Sidora is performing "Til the Dawn".
In 2008, Scott started working with music producer TommyD, under the name Graffiti6. The duo's song "Stare into the Sun" has been used by The Sun newspaper as part of the "Seize the summer" advertising campaign and also in the Dutch commercial for Wieckse beer. In late 2011 their music was used on Greys Anatomy, CSI New York and Covert Affairs. The pair signed with Capitol Records in the US. The album Colours was released on 24 January 2012. Their second album, The Bridge, was released independently on 21 April 2014.
In late 2015 Scott founded publishing company Catherine Songs and record label Catherine Records to facilitate up and coming songwriters and artists respectively. Scott is working with writers/producers Mike Needle (One Direction), and Dan Bryer (One Direction), as well as Catherine Records first signing, singer/songwriter River Matthews, with plans to release his music in 2016.