Janeway lesion

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Janeway lesion
Janeway lesion.JPG
Classification and external resources
Specialty infectious disease
ICD-10 A41.8 (ILDS A41.820)

Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1]

Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.[2]

Causes[edit]

Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[3] Janeway lesions are distal, flat, ecchymotic, and painless.

Etymology[edit]

Janeway lesions are named after Edward Janeway (1841–1911), a prominent American physician and pathologist who initially described the lesions.

See also[edit]

References[edit]

  1. ^ a b Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. PMID 947688. doi:10.1378/chest.70.2.239. 
  2. ^ Farrior JB, Silverman ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. PMID 947688. doi:10.1378/chest.70.2.239. 
  3. ^ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.