Cassini was born at the Paris Observatory. In 1784 he succeeded his father as director of the observatory; but his plans for its restoration and re-equipment were wrecked in 1793 by the animosity of the National Assembly. His position having become intolerable, he resigned on 6 September and was thrown into prison in 1794, but released after seven months. He then withdrew to Thury, where he died fifty-one years later.
Cassini’s Mémoires pour servir à l’histoire de l’observatoire de Paris (1810) embodied portions of an extensive work, the prospectus of which he had submitted to the Academy of Sciences in 1774. The volume included his Eloges of several academicians, and the autobiography of his great-grandfather, Giovanni Cassini.