Jean Pieters (2008)
|Institutions||University of Leuven, Maastricht University , European Molecular Biology Laboratory , Netherlands Cancer Institute in Amsterdam, Basel Institute for Immunology, Biozentrum University of Basel|
Jean Pieters studied biochemistry and microbiology at the University of Leuven in Belgium. After completing his doctorate at Maastricht University, the Netherlands, he joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1989 as a postdoctoral fellow. From 1992 until 1995 Jean Pieters researched at the Netherlands Cancer Institute in Amsterdam as a junior group leader. In 1996 he was recruited to the Basel Institute for Immunology and in 2002 appointed to the Biozentrum at the University of Basel where he since teaches and continues his research as Professor of Biochemistry.
Jean Pieters investigates the role of coronin proteins in activating cellular signal transduction processes. Coronin proteins are widely distributed in the eukaryotic kingdom and conserved from yeast to man. One of the most conserved members of this protein family, mammalian coronin 1, was originally discovered in his laboratory as a host factor responsible for the intracellular survival of pathogenic mycobacteria (Ferrari 1999). Subsequent work from his laboratory showed that coronin proteins regulate diverse physiologic processes including T cell homeostasis (Mueller 2008), learning and memory (Jayachandran 2014) and development (Vinet 2014). Recent work from his and other laboratories suggests that mutations in coronin proteins may underlie immune-related and cognitive disorders in humans, implicating coronin proteins in important physiological pathways.
Awards and honors
- 2011 Elected Corresponding Member of the Royal Netherlands Academy of Arts and Sciences
- 2002 Friedrich Miescher Award
- 2001 Pfizer Forschungspreis
- 1999 Eppendorf Young Investigator Award
- Jayachandran R., Liu X., BoseDasgupta S., Mueller P. et al. (2014) Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein kinase A Signaling. PLOS Biology, 12, e1001820; PMID 24667537
- Mueller, P., Massner, J., Jayachandran, R., et al. (2008). Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nat Immunol 9, 424-431; PMID 18345003
- Jayachandran R., Sundaramurthy V., et al. (2007). Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 130: 37-50; PMID 17632055
- Ferrari, G., Langen, H., M. Naito and Pieters, J. (1999). A phagosomal coat protein involved in the intracellular survival of mycobacteria. Cell, 97, 435-447. PMID 10338208
- Tulp A, Verwoerd D, Dobberstein B, Ploegh HL, Pieters J. 1994. Isolation and characterization of the intracellular MHC class II compartment. Nature 369: 120-6 (Full Article). PMID 8177317
- Elected Corresponding Member of the Royal Netherlands Academy of Arts and Sciences knaw.nl. Retrieved 2014-09-10.
- "Jean Pieters". Royal Netherlands Academy of Arts and Sciences. Retrieved 4 August 2015.
- The Awardees of the Friedrich Miescher-Award swissbiochem.ch. Retrieved 2014-09-10.
- Pfizer Forschungspreis, Preisträger 2001 Archived 2010-01-30 at the Wayback Machine. pfizerforschungspreis.ch. Retrieved 2014-09-10.
- Eppendorf Award for Young European Investigators, Past Award Winners eppendorf.com. Retrieved 2014-09-10.
- Full publication list biozentrum.unibas.ch. Retrieved 2014-09-17.