Jeff Clayton (born February 16, 1954) is an American jazz alto saxophonist and flautist.
Clayton studied oboe at California State University and undertook a tour with Stevie Wonder. Following this he recorded with Gladys Knight, Kenny Rogers, Michael Jackson, Patti Labelle, and Madonna. With his brother John Clayton he founded The Clayton Brothers in 1977, and later formed the Clayton-Hamilton Jazz Orchestra with Jeff Hamilton.
He has worked with Frank Sinatra, Sammy Davis Jr., Ella Fitzgerald, Woody Herman, Lionel Hampton, Ethan Smith, and Lena Horne, and played in the Count Basie Orchestra while under the leadership of Thad Jones. From 1989 to 1991 he was a member of the Phillip Morris Superband. He also toured with Gene Harris, Dianne Reeves, Joe Cocker, B.B. King and Ray Charles.
In December 2009 Brother To Brother by The Clayton Brothers received a Grammy nomination in the Best Jazz Instrumental Album, Individual or Group category.
- Boogie-Down, Ernestine Anderson and the Clayton-Hamilton Jazz Orchestra, 1989
- Groove Shop, Clayton-Hamilton Jazz Orchestra (George Bohannon, Oscar Brashear, Bobby Bryant, Lee Callet, Jeff Clayton, John Clayton, Bill Green, Thurman Green, Jeff Hamilton, Bob Hardaway, Clay Jenkins, Michael Lang, Doug MacDonald, Herb Mickman, Ira Nepus, Maurice Spears, Rickey Woodard, Snooky Young), 1989
- Heart and Soul, Clayton-Hamilton Jazz Orchestra, 1991
- Music, The Clayton Brothers (John Clayton, Jeff Clayton, Bill Cunliffe, Jeff Hamilton), 1991
- Absolutely, Clayton-Hamilton Jazz Orchestra, 1995
- Expressions, The Clayton Brothers (John Clayton, Jeff Clayton, Bill Cunliffe, Herlin Riley), 1997
- Explosive!, Milt Jackson and the Clayton-Hamilton Jazz Orchestra, 1999
- Siblingity, The Clayton Brothers (John Clayton, Jeff Clayton, Bill Cunliffe, Jeff Hamilton, Terell Stafford), 2000
- Back in the Swing of Things, The Clayton Brothers, 2005
- Christmas Songs, Diana Krall and the Clayton-Hamilton Jazz Orchestra, 2005
- Clayton-Hamilton Jazz Orchestra: Live at MCG, 2005
- Flirting With Twilight, Kurt Elling, 2001