Artistic from an early age, he started his career as a self-taught designer. He founded his design firm Jeremiah Brent Design (JBD) in 2011, a full service interior design firm with locations in both Los Angeles and New York City. The firm specializes in residential, commercial, and hospitality design.
Brent was featured in many television shows with a big break in 2011 when he became a styling associate to Rachel Zoe on her syndicated show The Rachel Zoe Project in the fourth season of the show. He has also appeared in covers of various publications such as Domino magazine, Architectural Digest, Harper's Bazaar and People magazine. He was host of the Emmy Award-winning show Home Made Simple, broadcast for two seasons on Oprah Winfrey's OWN network. Alongside his husband, fellow interior designer Nate Berkus, he launched in 2017 the TV show Nate & Jeremiah by Design broadcast on TLC network. In 2017, he also became part of Living Spaces particularly Living Spaces presents Behind the Design.
Brent is openly gay. After nearly a year of dating, he became engaged to fellow interior designer Nate Berkus in April 2013. They were married on May 4, 2014 in Manhattan. Their daughter, Poppy Brent-Berkus, was born on March 23, 2015 and their son, Oskar Michael Brent-Berkus, was born on March 26, 2018, both via surrogates.  Brent and his family currently live in West Hollywood, California.
In early 2014, they were featured in clothier Banana Republic's "True Outfitters" ads in InStyle and Rolling Stone, among other magazines. The New York Times noted they were the first same-sex couple to be featured in ads for the magazines. Their Manhattan apartment was featured in the September 2015 issue of Architectural Digest magazine, where Jeremiah Brent and Nate Berkus appeared on the cover with their daughter Poppy.
- "Jeremiah Brent and Nate Berkus Proposal Story".
- Boehm, Kristin; Triggs, Charlotte (April 10, 2013). "Nate Berkus Is Engaged to Jeremiah Brent". People.
- "Jeremiah Brent and Nate Berkus Wedding Pictures".
- Webber, Stephanie (May 3, 2014). "Nate Berkus Marries Fiance Jeremiah Brent in NYC: New Details on Ceremony, Reception". Us Weekly. Retrieved May 5, 2014.
- "Jeremiah Brent and Nate Berkus Surrogate Born Son and Daughter".
- "Jeremiah & I are thrilled to announce..." Nate Berkus verified Facebook pager. March 25, 2015. Retrieved March 25, 2015.
- Huffington Post: Nate Berkus Welcomes A Daughter, Poppy Brent-Berkus
- PopSugar: Nate Berkus and Jeremiah Brent's Snaps of Their Daughter, Poppy, Are Devastatingly Sweet
- Nate Berkus And Jeremiah Brent Star In Banana Republic Campaign
- Republic Ads With Real-Life Unions Include a Gay Couple
- "Jeremiah Brent and Daughter Poppy Brent Berkus at Disneyland".
- PopSugar: Inside Nate Berkus and Jeremiah Brent's New Home With Baby Poppy