Cameron made his debut in Greater Western Sydney's first AFL premiership game in Round 1 2012, against Sydney. In round 2, Cameron kicked 4 goals against North Melbourne and was awarded the round 2 nomination for the 2012 AFL Rising Star. In round 5, Cameron kicked 5 goals against the Western Bulldogs, becoming the first GWS player to kick 5 goals in a match. He finished the year as the club's leading goalkicker with 29 goals.
In 2013, Cameron continued to show his potential in a young GWS side. He received a Goal of the Year nomination for an excellent goal he kicked against Geelong in Round 11, one of four he kicked for the match. His game has already been likened to that of Matthew Lloyd and Jonathan Brown.
In Round 18 against Collingwood, Cameron kicked seven goals in the first three quarters; this is the highest haul of goals by any GWS player. He finished the season third on the Coleman Medal tally with 62 goals for the season.
Caneron is regarded as one of the most promising Centre Half Forwards in the game, for his age. Cameron equalled his career best of seven goals in Round 6, 2015 as the Giants defeated two-time reigning premiers Hawthorn by 10 points. His haul of seven was also the highest by a Giants player at Sydney Showground Stadium.