On April 28, 2012 Lane was drafted in the NFL Draft by the Seattle Seahawks with the 172nd pick overall in the sixth round. On May 7, 2012, he agreed to contract terms. During the 2013 NFL season, Lane won his first Super Bowl ring as a member of the Seahawks.
Lane recorded his first career interception in Super Bowl XLIX, picking off a pass at the goal-line in the first quarter. It proved costly, however, as on the interception return Lane would suffer a severe arm injury after being tackled by Julian Edelman, and did not return to the game, an eventual loss.