The farm and the complex, started in 1615, had to be left by the Jesuits, following the 1767 decree by King Charles III of Spain that expelled them from the continent. They were then run by the Franciscans until 1853, when the Jesuits returned to The Americas. Nevertheless, the university and the high-school were nationalized a year later.
Each Estancia has its own church and set of buildings, around which towns grew, such as Alta Gracia, the closest to the Block. The Estancia San Ignacio no longer exists. The Jesuit Block and the Estancias can be visited by tourists; the Road of the Jesuit Estancias has around 250 kilometres of length.
Jorge Mario Bergoglio, who would later become pope Francis lived there.