Perkins was selected by the Charlotte Sting with the 35th pick in the 2004 WNBA Draft. Perkins missed most of the season due to the birth of her daughter.
On November 16, 2005, Perkins was selected by the Chicago Sky in the expansion draft. She played in Chicago for five years and posted a career-best 17.0 points per game in 2008.
In 2009, Perkins was named to the Eastern Conference All-Star team as a reserve.
Prior to the 2011 season, she was traded to the San Antonio Stars in exchange for Michelle Snow. The Silver Stars qualified for the playoffs and Perkins made her first career postseason appearance in 2011.