Meleán joined the cast of MADtv in 2002, as a featured performer, for the seventh season. She was the second HispanicMADtv cast member (The first was Cuban born Nelson Ascencio in 1999) and the first Latin female to join the show. However, unlike Ascencio, it was not her portrayal of famous Latin stars that got her her big break on the show. Her first skit, a parody of Britney Spears' "Not a Girl" video, quickly gained her fans and notoriety. As a result, Meleán was promoted to repertory status for the following season.