This article needs to be updated.February 2020)(
Joachim Boldt (born September 29, 1954) is a German anesthesiologist who was previously considered a leading researcher of medicinal colloids. He was an advocate for the use of collodial hydroxyethyl starch to boost blood pressure during surgery. He has been stripped of his professorship and is under criminal investigation for possible forgery of up to 90 research studies.
The editors of 16 different scientific journals, including Anesthesia & Analgesia, Anaesthesia, the European Journal of Anaesthesiology, and the British Journal of Anaesthesia, allege that 89 of 102 studies published by Boldt contained research without proper institutional review board approval.
On November 10, 2010, Boldt was suspended from Klinikum Ludwigshafen, a hospital in Germany, for a scientific publication in Anesthesia & Analgesia with insufficient background research. His field of research and the publications were related to hydroxyethyl starch (HES). Some 90 studies he published are currently being reviewed by medical authorities.
In February 2011, Boldt was stripped of his title of professor at the University of Giessen for failing to teach, and the university is investigating possible charges of scientific misconduct. His case was described at the time as "possibly the biggest medical research scandal since Andrew Wakefield was struck off in 2010 for falsely claiming to have proved a link between the MMR vaccine and autism".
In August 2012, the hospital released the results of the investigation: while no patients were harmed, "in a large number of the studies investigated, the conduct of research failed to meet required standards. False data were published in at least 10 of the 91 articles examined, including, for instance, data on patient numbers/ study groups as well as data on the timing of measurements".
On February 20, 2013, JAMA published a meta-analysis on HES in critically ill patients. Boldt had 7 studies from the 1990s that had not yet been retracted. Including them, there was no increase in mortality, but excluding them, there was a significant increase in mortality. Only the Boldt studies showed an improvement with HES; all other studies showed no benefit but significant risks. It is believed that his fraudulent studies put critically ill patients at risk and caused harm.
An overview of the challenges for meta-analysts presented by the fraud has recently been published. It includes double publication of studies, manipulating demographic and outcome data to conceal double publication, and getting better results for a drug being tested.
By 2017, 96 of Boldt's papers had been retracted. In October 2018, a review highlighted additional retractions with the oldest retracted paper from 1986, demonstrating persistent fraud for Boldt's entire career. Statistical analyses demonstrate that it is likely that many fraudulent papers from Boldt remain and editors should take action. In December 2019, three more of his clinical trials were retracted, bringing the total to 100, the second highest number of retractions among all researchers according to Retraction Watch.
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- Press release, Klinikum Ludwigshafen, http://www.klilu.de/content/aktuelles___presse/pressearchiv/2012/hospital_presents_results_of_final_report_committee_completes_investigation_in_the_case_of_dr_boldt/index_ger.html Archived 2012-10-22 at the Wayback Machine, 9 August 2012
- Zarychanski, Ryan; Abou-Setta, Ahmed M.; Turgeon, Alexis F.; Houston, Brett L.; McIntyre, Lauralyn; Marshall, John C.; Fergusson, Dean A. (2013). "Association of Hydroxyethyl Starch Administration with Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation". JAMA. 309 (7): 678–88. doi:10.1001/jama.2013.430. PMID 23423413.
- Antonelli, Massimo; Sandroni, Claudio (2013). "Hydroxyethyl Starch for Intravenous Volume Replacement". JAMA. 309 (7): 723–4. doi:10.1001/jama.2013.851. PMID 23423420.
- Wilkes, Mahlon M.; Navickis, Roberta J. (2013). "The Boldt affair: a quandary for meta-analysts". Anesthesiology News. 39 (4): 8–9.
- "The Retraction Watch Leaderboard". 2015-06-16.
- Wiedermann, Christian J.; Joannidis, Michael (2018). "The Boldt scandal still in need of action: The example of colloids 10 years after initial suspicion of fraud". Intensive Care Medicine. 44 (10): 1735–1737. doi:10.1007/s00134-018-5289-3. PMID 29968012.
- "Joachim Boldt retractions". Retraction Watch.