Joan Massagué

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Joan Massagué
Joan Massagué in suit.jpg
Born(1953-04-30)April 30, 1953
Alma materUniversity of Barcelona, Brown University
Known forcancer metastasis
Scientific career
Fieldscancer biology
InstitutionsMemorial Sloan-Kettering Cancer Center, Institute for Research in Biomedicine

Joan Massagué (born April 30, 1953 in Barcelona), is a pharmacist and the current director of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center. He is also an internationally recognized leader in the study of both cancer metastasis and growth factors that regulate cell behavior, as well as a professor at the Weill Cornell Graduate School of Medical Sciences.[1]

Education and career[edit]

Born in Barcelona, Spain, on April 30, 1953, Massagué earned his doctorate degree in biochemistry at the University of Barcelona in 1978 under the mentorship of Professor Joan J. Guinovart.[citation needed] He completed a postdoctoral fellowship in 1982 in the laboratory of Michael P. Czech, PhD, at Brown University, where he determined the composition of the receptor for the hormone insulin. Later that year, he became an assistant professor in biochemistry at the University of Massachusetts Medical School in Worcester.[2]

Massagué joined Memorial Sloan Kettering in 1989 as the Alfred P. Sloan Chair of the Sloan Kettering Institute’s Cell Biology Program and was named founding Chair of the Cancer Biology and Genetics Program in 2003.[2] Additionally, he has served as a Scientific Advisor at the Institute for Research in Biomedicine in Barcelona since 2005.[3]

He was an investigator at the Howard Hughes Medical Institute from 1990 to 2013.[4] In 2014, he joined HHMI’s Scientific Review Board.[5] In 2013, Massagué was named Director of the Sloan Kettering Institute.[6]

Scientific contributions[edit]

Massagué is credited with establishing the dual role of TGFβ, which can both inhibit and activate tumor cell growth, and identifying its importance in cancer.[4] His work identified the TGF-β receptors and cell signaling pathway, and defined the central concept of how this pathway controls cell fate.[7]

In 2003, Dr. Massagué and colleagues documented the effects of the gain or loss of the TGF-β pathway in a mouse model of breast cancer, showing that it can increase lung metastases but suppress the growth of primary tumors.[8] That same year, he published another paper that found that two genes expressed in breast cancer were increased in the presence of TGF-β and enabled the tumor cells to metastasize to the bone.[9]

In 2005, Dr. Massagué and his team published a study that identified which breast cancer cells expressing an identified set of genes associated with metastasis were destined to spread to the lung versus elsewhere.[10] Later work characterized gene sets and pathways in human cancer cells that enable breast and lung tumor cells to invade and colonize the brain.[11][12]

Since 2009, his lab has published research on tumor self-seeding by circulating cancer cells, a process by which disseminated metastatic cells that resist cancer therapy re-infiltrate tissues to expand as highly aggressive clones.[13] His lab also found that disseminated cancer cells use the cell adhesion molecule L1CAM to coopt blood capillaries for the initiation of metastatic outgrowth.[14] In 2016, Massagué and his group defined the basis for metastatic latency in breast and lung cancers, and the interplay of metastatic stem cells with the innate immune system.[15]

Awards and honors[edit]

References[edit]

  1. ^ "Joan Massague | Graduate School of Medical Sciences". gradschool.weill.cornell.edu. Retrieved 31 August 2017.
  2. ^ a b Gittelson, Celia (25 Nov 2013). "Cancer Biologist Joan Massagué Named Director of the Sloan Kettering Institute". www.mskcc.org. Retrieved 31 August 2017.
  3. ^ "Joan Massagué joins IRB Barcelona". www.irbbarcelona.org. Retrieved 31 August 2017.
  4. ^ a b Elizabath Davita-Raeburn for the HHMI Bulletin. August 2008. The Unintentional Scientist
  5. ^ "Scientific Review Board". HHMI.org. Retrieved 15 June 2017.
  6. ^ [1], Memorial Sloan Kettering Cancer Center.
  7. ^ Shi, Y; Massagué, J (13 June 2003). "Mechanisms of TGF-beta signaling from cell membrane to the nucleus". Cell. 113 (6): 685–700. ISSN 0092-8674. PMID 12809600.
  8. ^ Siegel, P. M.; Shu, W.; Cardiff, R. D.; Muller, W. J.; Massague, J. (13 June 2003). "Transforming growth factor signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis". Proceedings of the National Academy of Sciences. 100 (14): 8430–8435. doi:10.1073/pnas.0932636100. PMC 166246. PMID 12808151.
  9. ^ Kang, Y; Siegel, PM; Shu, W; Drobnjak, M; Kakonen, SM; Cordón-Cardo, C; Guise, TA; Massagué, J (June 2003). "A multigenic program mediating breast cancer metastasis to bone". Cancer Cell. 3 (6): 537–49. PMID 12842083.
  10. ^ Minn, AJ; Gupta, GP; Siegel, PM; Bos, PD; Shu, W; Giri, DD; Viale, A; Olshen, AB; Gerald, WL; Massagué, J (28 July 2005). "Genes that mediate breast cancer metastasis to lung". Nature. 436 (7050): 518–24. doi:10.1038/nature03799. PMC 1283098. PMID 16049480.
  11. ^ Nguyen, Don X.; Chiang, Anne C.; Zhang, Xiang H.-F.; Kim, Juliet Y.; Kris, Mark G.; Ladanyi, Marc; Gerald, William L.; Massagué, Joan (July 2009). "WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis". Cell. 138 (1): 51–62. doi:10.1016/j.cell.2009.04.030. PMC 2742946. PMID 19576624.
  12. ^ Bos, Paula D.; Zhang, Xiang H.-F.; Nadal, Cristina; Shu, Weiping; Gomis, Roger R.; Nguyen, Don X.; Minn, Andy J.; van de Vijver, Marc J.; Gerald, William L.; Foekens, John A.; Massagué, Joan (6 May 2009). "Genes that mediate breast cancer metastasis to the brain". Nature. 459 (7249): 1005–1009. doi:10.1038/nature08021. PMC 2698953. PMID 19421193.
  13. ^ Kim, Mi-Young; Oskarsson, Thordur; Acharyya, Swarnali; Nguyen, Don X.; Zhang, Xiang H.-F.; Norton, Larry; Massagué, Joan (December 2009). "Tumor Self-Seeding by Circulating Cancer Cells". Cell. 139 (7): 1315–1326. doi:10.1016/j.cell.2009.11.025. PMC 2810531. PMID 20064377.
  14. ^ Valiente, Manuel; Obenauf, Anna C.; Jin, Xin; Chen, Qing; Zhang, Xiang H.-F.; Lee, Derek J.; Chaft, Jamie E.; Kris, Mark G.; Huse, Jason T.; Brogi, Edi; Massagué, Joan (February 2014). "Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis". Cell. 156 (5): 1002–1016. doi:10.1016/j.cell.2014.01.040. PMC 3988473. PMID 24581498.
  15. ^ Malladi, Srinivas; Macalinao, Danilo G.; Jin, Xin; He, Lan; Basnet, Harihar; Zou, Yilong; de Stanchina, Elisa; Massagué, Joan (March 2016). "Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT". Cell. 165 (1): 45–60. doi:10.1016/j.cell.2016.02.025. PMC 4808520. PMID 27015306.
  16. ^ "Joan Massagué, PhD, to Receive 2016 Pezcoller Foundation–AACR International Award for Cancer Research". The ASCO Post. Retrieved 19 April 2017.
  17. ^ "Joan Massagué, PhD". Retrieved 19 April 2017.
  18. ^ "Brupbacher Preis". Charles Rodolphe Brupbacher Stiftung (in French). 6 February 2017. Retrieved 19 April 2017.
  19. ^ "Professor Peter Ratcliffe receives Pasarow Award in Cardiovascular Disease - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 19 April 2017.
  20. ^ "BBVA Foundation Frontiers of Knowledge Awards". www.fbbva.es. Retrieved 2016-07-04.
  21. ^ "Past Recipients - The Passano Foundation, Inc". passanofoundation.org. Retrieved 6 April 2017.
  22. ^ "Joan Massagué Wins Vilcek Prize | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 2015-11-11.
  23. ^ "Member". National Academy of Medicine. Retrieved 17 May 2017.
  24. ^ "Judah Folkman, Tony Hunter, Joan Massagué, Bert Vogelstein and Robert A. Weinberg - Laureates - Princess of Asturias Awards - The Princess of Asturias Foundation". The Princess of Asturias Foundation. Retrieved 6 April 2017.
  25. ^ http://www.nasonline.org, National Academy of Sciences -. "Joan Massague". www.nasonline.org. Retrieved 17 May 2017.
  26. ^ "Academy of Arts & Sciences Website Search". www.amacad.org. Retrieved 17 May 2017.