Patfull was recruited onto the Port Adelaide rookie list in 2003, but was dropped at the end of the 2004 season. He was then recruited to the Brisbane Lions as the number 56 draft pick in the 2005 AFL Draft.
He made his senior debut for the Brisbane Lions in Round 8, 2006 against his former club, Port Adelaide where he scored a goal with his first kick of AFL football. He went on to play the remaining 15 games of the 2006 season.
After the 2006 AFL season, it was speculated in the media that Patfull was enticed to return to Adelaide by the Adelaide Crows and Port Adelaide Power, however his manager announced in mid-November that Patfull had accepted a two-year contract to continue his career with the Brisbane Lions. While not a flashy player, Patfull's discipline and work ethic have made him a respected player amongst Brisbane supporters.
In 2012 he was awarded the Brisbane Lions Club Champion award (Merrett-Murray Medal) with 34 votes. He was also awarded the Shaun Hart Most Courageous Player for 2012.