Giesecke was born in Stockholm. He defended his thesis, On The Molecular Structure Of Dopaminergic Substances, at the Karolinska Institute. He trained as an infectious disease clinician and worked with AIDS patients during the 1980s. Giesecke received an MSc in epidemiology from the London School of Hygiene and Tropical Medicine in 1992, after which he worked as a Senior Lecturer at the school.
From 1995 to 2005, Giesecke served as state epidemiologist of Sweden. During a one-year sabbatical 1999-2000 he led a group at the World Health Organization working on the revision of the International Health Regulations. After this, he was Chief Scientist at the European Centre for Disease Prevention and Control from 2005 to 2014. As of 2020, Giesecke is a member of the Strategic and Technical Advisory Group for Infectious Hazards of the World Health Organization, and also works as an advisor to the Public Health Agency of Sweden during the COVID-19 pandemic in Sweden.
- On The Molecular Structure Of Dopaminergic Substances (Balder, 1979)
- Modern Infectious Disease Epidemiology (Edward Arnold, 1994)
- Att förebygga HIV: Psykosocialt omhändertagande vid kontaktspårning (Studentlitteratur, 1991)
- "Giesecke: Forskare bör hålla sig i sina områden". Svenska Dagbladet (in Swedish). 2020-03-23. ISSN 1101-2412. Retrieved 2020-04-18.
- Giesecke, Johan (1979). On the molecular structure of dopaminergic substances. Stockholm: Balder.
- "WHO | Members of the Strategic and Technical Advisory Group for Infectious Hazards (STAG-IH)". WHO. Retrieved 2020-04-18.
- "Giesecke: "Alla andra länder gör fel"". Dagens industri. 3 April 2020. Retrieved 24 April 2020. CS1 maint: discouraged parameter (link)
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