John C. Crabbe

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John C. Crabbe
EducationStanford University
University of Colorado
Known forMouse models of alcoholism
Awards2015 Marlatt Mentorship Award from the Research Society on Alcoholism[1]
Scientific career
InstitutionsOregon Health & Science University
ThesisEffects of D-amphetamine on learning and memory in inbred and hybrid mice (1973)
Doctoral advisorHerbert Alpern

John C. Crabbe, Jr. is an American neuroscientist and behavior geneticist. He is a professor of behavioral neuroscience at the Oregon Health & Science University (OHSU) School of Medicine, where he has worked since 1979.[2] He is also a senior research career scientist at the Veterans Affairs Medical Center in Portland, Oregon.[1] He is also the former director of OHSU's Portland Alcohol Research Center.[3][4]

Crabbe is known for his research using mouse models to study the pharmacogenetics of alcoholism.[3][5] He is also known for a 1999 study he and his colleagues published documenting significant variations in certain mouse behaviors across different labs, even when they all tried to follow the same protocols.[6][7][8] In 2011, he was chosen by the National Institute on Alcohol Abuse and Alcoholism to give the 16th annual Mark Keller Honorary Lecture.[2]

Crabbe is a member of the editorial board of Genes, Brain and Behavior.[9]


  1. ^ a b "Dual-appointed VA and SoM faculty set record for outside research support". Oregon Health & Science University (Press release). 2017-02-13. Retrieved 2018-06-29.
  2. ^ a b "Dr. Crabbe honored by National Institute on Alcohol Abuse and Alcoholism". Oregon Health & Science University (Press release). Retrieved 2018-06-29.
  3. ^ a b "John C. Crabbe, Ph.D." Oregon Health & Science University. Retrieved 2018-06-29.
  4. ^ News, OHSU (2008-08-07). "OHSU Receives $1.3 Million Legacy to Advance Research into the Genetic Causes of Alcoholism". OHSU News (Press release). Retrieved 2018-06-29. {{cite press release}}: |last1= has generic name (help)
  5. ^ Gordon, Serena (2002-05-15). "Gene Discovery May Help Explain Alcoholism". Consumer HealthDay. Retrieved 2018-06-29.
  6. ^ Crabbe, John C.; Wahlsten, Douglas; Dudek, Bruce C. (1999-06-04). "Genetics of Mouse Behavior: Interactions with Laboratory Environment". Science. 284 (5420): 1670–1672. Bibcode:1999Sci...284.1670C. doi:10.1126/science.284.5420.1670. ISSN 0036-8075. PMID 10356397. S2CID 18263913.
  7. ^ Enserink, Martin (1999-06-03). "Fickle Mice Highlight Gene-Behavior Woes". Science. Retrieved 2018-06-29.
  8. ^ Laursen, Lucas (2009-03-30). "Experimental design could reduce need for animal tests". Nature. doi:10.1038/news.2009.209. Retrieved 2018-06-29.
  9. ^ "Genes, Brain and Behavior". Wiley-Blackwell. Retrieved 2019-01-27.