|Sir John Cornforth|
|Born||John Warcup Cornforth, Jr.
7 September 1917
|Died||14 December 2013
Sussex, England, United Kingdom
|Residence||Brighton, United Kingdom|
|Thesis||Synthesis of analogues of steroid hormones (1941)|
|Doctoral advisor||Robert Robinson|
|Known for||Stereochemistry of enzyme-catalysed reactions|
Sir John Warcup "Kappa" Cornforth, Jr., AC, CBE, FRS, FAA (7 September 1917 – 8 December 2013), was an Australian–British chemist who won the Nobel Prize in Chemistry in 1975 for his work on the stereochemistry of enzyme-catalysed reactions, becoming the only Nobel laureate born in New South Wales.
Cornforth investigated enzymes that catalyse changes in organic compounds, the substrates, by taking the place of hydrogen atoms in a substrate's chains and rings. In his syntheses and descriptions of the structure of various terpenes, olefins, and steroids, Cornforth determined specifically which cluster of hydrogen atoms in a substrate were replaced by an enzyme to effect a given change in the substrate, allowing him to detail the biosynthesis of cholesterol. For this work, he won a share of the Nobel Prize in Chemistry in 1975, alongside co-recipient Vladimir Prelog, and was knighted in 1977.
Born in Sydney, New South Wales, Cornforth was the son and the second of four children of English-born, Oxford-educated schoolmaster and teacher John Warcup Cornforth and Hilda Eipper (1887–1969), a granddaughter of pioneering missionary and Presbyterian minister Christopher Eipper. Before her marriage, Eipper had been a maternity nurse.
At about 10 years old, Cornforth had noted signs of deafness, which led to a diagnosis of otosclerosis, a disease of the inner ear which causes progressive hearing loss. This would leave him completely deaf by the age of 20 but also fatefully influence his career direction towards chemistry.
Cornforth was educated at Sydney Boys' High School, whereat he academically excelled, passed tests in English, mathematics, science, French, Greek, and Latin, and was inspired by his chemistry teacher, Leonard ("Len") Basser, to change his career directions from the law to chemistry. Cornforth graduated as the dux of the class of 1933 at Sydney Boys' High School, at the age of 16.
In 1934, Cornforth matriculated and studied at the University of Sydney, where he studied organic chemistry at the University of Sydney's School of Chemistry and from which he graduated with a Bachelor of Science with First-Class Honours and the University Medal in 1937. During his studies, his hearing became progressively worse, thus making listening to lectures difficult. At the time, he could not use hearing aids as the sound became distorted, and he did not significantly use lip reading.
While studying at the University of Sydney, Cornforth met his future wife, fellow chemist, and scientific collaborator, Rita Harradence. Harradence was a graduate of St George Girls High School and a distinguished academic achiever who had topped the state in Chemistry in the New South Wales Leaving Certificate Examination. Harradence graduated with a Bachelor of Science with First-Class Honours and the University Medal in Organic Chemistry in 1936, a year ahead of Cornforth. Harradence also graduated with a M.Sc. in 1937, writing a master's thesis titled "Attempts to synthesise the pyridine analogue of vitamin B1".
In 1939, Cornforth and Harradence, independently of each other, each won one of two Science Research Scholarships (the 1851 Research Fellowship) from the Royal Commission for the Exhibition of 1851, tenable overseas for two years. At the University of Oxford, they were members of St. Catherine's College and worked with Sir Robert Robinson, with whom they would collaborate for 14 years. During his time at Oxford, Cornforth found working for and with Robinson stimulating, and the two would often deliberate to no end until one had a cogent case against the other's counterargument. In 1941, Cornforth and Harradence both graduated with a D.Phil. in Organic Chemistry. At the time, there were no institutions or facilities at which a Ph.D. in chemistry could be done in Australia.
After his arrival at Oxford and during World War II, Cornforth significantly influenced the work on penicillin, particularly in purifying and concentrating it. Penicillin is usually very unstable in its crude form; as a consequence of this, researchers at the time were building upon Howard Florey's work on the drug. In 1940, Cornforth and other chemists measured the yield of penicillin in arbitrary units to understand the conditions that favoured penicillin production and activity, and he contributed to the authoring of The Chemistry of Penicillin.
In 1946, Cornforth and his wife, Rita, left Oxford and joined the Medical Research Council, working at the National Institute for Medical Research (NIMR), where they continued on earlier work in synthesising sterols, including cholesterol. The Cornforths collaboration with Robinson continued and flourished. In 1951, they completed, simultaneously with Woodward, the first total synthesis of the non-aromatic steroids. At the NIMR, Cornforth collaborated with numerous biological scientists, including George Popják, with whom he shared an interest in cholesterol. Together, they received the Davy Medal in 1968 in recognition of their distinguished joint work on the elucidation of the biosynthetic pathway to polyisoprenoids and steroids.
In 1941, the year in which they graduated from the University of Oxford, Cornforth married Rita Harriet Harradence (b. 1915), with whom he would have one son and two daughters, John and Brenda and Philippa, respectively. Cornforth met Harradence after she had broken a Claisen flask in their second year at the University; Cornforth, with his expertise of glassblowing and the use of a blowpipe, mended the break. Rita Cornforth died on 6 November 2012, at home with her family around her, following a long illness.
Honours and awards
- Corday–Morgan Medal (1953)
- Davy Medal (1968)
- Elected a Fellow of the Royal Society (FRS) in 1953
- Commander of the Order of the British Empire (CBE; 1972)
- Nobel Prize in Chemistry (1975)
- Royal Medal (1976)
- Knight Bachelor (1977)
- Corresponding Fellow of the Australian Academy of Science (1977)
- Foreign member of the Royal Netherlands Academy of Arts and Sciences (since 1978)
- Copley Medal (1982)
- Companion of the Order of Australia (AC; 1991)
- Centenary Medal (2001)
Cornforth's certificate of election for the Royal Society reads:
|“||Distinguished as an Organic Chemist of outstanding originality and exceptional experimental skill, particularly in microchemical manipulation. He was the first to attribute the correct constitution to penicillamine and to synthesise the amino-acid. After making significant contributions to the synthesis of penicillin he notably developed the chemistry of the oxazole group and made oxazole itself for the first time.
The important share he took in the total synthesis of androgenic hormones and other steroids is gratefully recognised by all his collaborators in the investigation. Miscellaneous work on natural products and chemotherapy equally displays individual thought, invention, and superlative technical accomplishment.
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