John Fraser (surgeon)
|Born||23 March 1885|
Tain, Rosshire, Scotland
|Died||1 December 1947 (aged 62)|
|Known for||Establishing M. bovis as a cause of human TB. Fluid replacement in surgical shock. Ligation patent ductus arteriosus|
|Title||Regius Professor of Clinical Surgery, University of Edinburgh. Principal, University of Edinburgh|
|Spouse(s)||Agnes Govane Herald|
|Education||Tain Royal Academy|
|Alma mater||University of Edinburgh|
|Thesis||An aetiological and pathological study of tuberculosis of the bones and joints (1912)|
Sir John Fraser Bt KCVO MC FRSE FRSEd (23 March 1885 – 1 December 1947) was Regius Professor of Clinical Surgery at Edinburgh University from 1925 to 1944 and served as principal of the University of Edinburgh from 1944 to 1947.
His study of tuberculosis in children was to disprove the view of the Nobel prize winner Robert Koch that bovine tuberculosis did not play a major pathogenic role in human disease. The subsequent legislation led to the elimination of tuberculosis from milk supplies and resulted in a decline in incidence of bone and joint tuberculosis in children. In 1940 he was the first surgeon in Britain to ligate an uninfected patent ductus arteriosus.
Early life and family
Fraser, whose parents both came from families of farmers, was born 23 March 1885 in Tain, Rosshire. He was a few months old when his father died and he was raised as an only child by his mother. He went on to attend Tain Royal Academy. He then studied medicine, gaining admission to the medical faculty at the University of Edinburgh in 1902, graduating MB ChB with honours in 1907, winning the Allan Fellowship in Clinical Medicine and the gold medal for Clinical Surgery.
Fraser's son, Sir James Fraser, also became a surgeon and president of the Royal College of Surgeons of Edinburgh.
Early medical career
Fraser served as house surgeon, first in the Royal Infirmary of Edinburgh and then at the Royal Hospital for Sick Children under Sir Harold Stiles, who was to have a powerful influence on Fraser's approach to surgical problems and scientific enquiry. He became a fellow of the Royal College of Surgeons of Edinburgh (FRCSEd) in 1910.
Fraser's scientific approach was manifest in his ChM dissertation, nominally on inguinal hernia in childhood but containing a detailed account of the descent of the testis which was based on 1000 cases he studied and which contained many original observations. The dissertation was awarded the Lister Prize for surgery.
Research into tuberculosis
For his MD thesis he studied the pathology and aetiology of tuberculosis of bones and joints. As Stiles had treated bone and joint TB in children by radical excision there was a large pathological collection available for study. He set out to investigate the claim by Robert Koch that the risk of humans acquiring TB by drinking milk from tuberculous cows was negligible. This view was not supported by laboratory experiments commissioned by a British royal commission. Fraser disproved Koch's view by demonstrating that 60% of the bones and joints he examined had the bovine form of the causative organism, Mycobacterium bovis. He went on to demonstrate the organism in local milk supplies and called for widespread pasteurisation of milk with increased regulation. The subsequent legislation led to the elimination of tuberculosis from milk supplies and resulted in a decline in incidence of bone and joint tuberculosis in children. Fraser's 1912 MD thesis was awarded a gold medal.
First World War
Fraser was commissioned in the Royal Army Medical Corps (RAMC) in August 1914. He served on the Western Front as Regimental Medical Officer in the First Cavalry Division and then, as surgeon to a casualty clearing station, he treated the wounded from the Battle of Loos. In 1916 he was wounded, was mentioned in dispatches and received the Military Cross.
During this wartime service, he wrote papers on treatment of abdominal wounds, on the treatment of gas gangrene with Eusol (a solution of hypochlorous acid) and on shock and its treatment with gum saline and other intravenous infusions. His studies on blood pressure in shock resulted in his being invited to join the Medical Research Committee's small group on surgical shock whose other members included distinguished physiologists like E H Starling, W M Bayliss and the future Nobel laureates C S Sherrington and Henry Dale.
Fraser's wartime observations were a major contribution to this committee who were to pioneer the scientific basis of fluid replacement in surgical shock.
While an army surgeon, he was successful in stitching up a gunshot wound of a heart.
He produced a book with Cuthbert Wallace about his medical experiences during the war, Surgery at a Casualty Clearing Station, which was published by A & C Black in 1918. Many of the illustrations were produced by Fraser's wife.
Post-war medical career
On his return to Edinburgh, he was appointed surgeon to the Royal Hospital for Sick Children and the Royal Infirmary. In 1924 he was appointed to the Regius Chair of Clinical Surgery in succession to Sir Harold Stiles. He was elected a fellow of the Royal Society of Edinburgh in 1928, his proposers being Arthur Logan Turner, Harold Stiles, Arthur Robinson, James Hartley Ashworth and Sir James Arthur Ewing.
He chaired the Advisory Committee on Blood Transfusion which set up blood banks in Scotland in 1939.
Fraser's surgical career encompassed paediatric, abdominal, cardiothoracic and breast surgery and he wrote extensively on all of these. At a time when surgery on the heart was unthinkable, Fraser kept his interest in its possibility. On 19 October 1940 he became the first surgeon in the British Isles to successfully ligate an uninfected patent ductus arteriosus, two weeks after Oswald Tubbs had successfully ligated an infected ductus in London. Robert Gross had performed the first in Boston in 1938. Before retiring from surgery Fraser operated on 12 such cases. In addition, he had performed left cervical sympathectomy for angina. His experience with O'Shaughnessy's cardio-omentopexy surgery was less successful.
Death and legacy
The workload strain of the Second World War contributed to his deteriorating health, and following his guided smooth transition of the university from war time to peacetime, Sir John Fraser died in Edinburgh on 1 December 1947.
He was Surgeon to the King in Scotland, and was created a Knight Commander of the Victorian Order (KCVO) in 1937. In the 1943 Birthday Honours he was made a Baronet with the creation of the Fraser Baronetcy, of Tain in the County of Ross. He was awarded the honorary degree of LL.D. by the University of Edinburgh in 1944.
Thomas Henry Holland
| Principals of Edinburgh University
Edward Victor Appleton
- Tuberculosis of the bones and joints in children. London: A & C Black, 1914.
- Surgery at a Casualty Clearing Station (with Cuthbert Wallace). London: A & C Black, 1918.
- Surgery of Childhood. London: Arnold & Co, 1926.
- Surgeons' lives : Royal College of Surgeons of Edinburgh : an anthology of College Fellows over 500 years. Macintyre, Iain M. C., MacLaren, Iain., Royal College of Surgeons of Edinburgh. Edinburgh: Royal College of Surgeons of Edinburgh. 2005. pp. 188–189. ISBN 978-0950362090. OCLC 64773979.CS1 maint: others (link)
- Graham, J. M. (March 1951). "Sir John Fraser and his contributions to surgery". Edinburgh Medical Journal. 58 (3): 105–124. ISSN 0367-1038. PMC 5283103. PMID 14840381.
- "Sir John Fraser", The Times, 4 December 1947, p 6.
- Edinburgh., Royal College of Surgeons of (1995). Portraits, paintings & busts in the Royal College of Surgeons of Edinburgh. Masson, Alastair H. B. (Alastair Hugh Bailey). Edinburgh: The College. pp. 70–72. ISBN 978-0950362045. OCLC 33820105.
- Fraser, J. The study of 1000 cases of oblique inguinal hernia occurring in children. Thesis for the degree of ChM. University of Edinburgh, 1910.
- R. Koch "The relations of human and bovine tuberculosis", JAMA, 51 (1908), pp. 1256-1258
- Blevins, Steve M.; Bronze, Michael S. (1 September 2010). "Robert Koch and the 'golden age' of bacteriology". International Journal of Infectious Diseases. 14 (9): e744–e751. doi:10.1016/j.ijid.2009.12.003. ISSN 1201-9712. PMID 20413340.(subscription required)
- Royal Commission to Inquire into Effect of Food Derived from Tuberculous Animals on Human Health, British Parliamentary Papers 1895 (C7703) xxxv; 1896 (C7992) xlvi
- Atkins, P. J. (1999). "Milk consumption and tuberculosis in Britain, 1850-1950.', in Order and disorder : the health implications of eating and drinking in the nineteenth and twentieth centuries" (PDF). Dro.dur.ac.uk. Retrieved 2 April 2018.
- Addresses ... Annual Mid-western Tuberculosis Conference ... University of Wisconsin. 1928. p. 82.
- Fraser, J. "The pathology of tuberculosis in bones", Journal of Pathology and Bacteriology. 1912;17:254
- Fraser, J. "The relative prevalence of Human and Bovine types of Tubercule bacilli in bone and joint tuberculosis occurring in children", Journal of Experimental Medicine, 1912;16:432
- Bernard, Marie-Catherine (2003). "Tuberculosis: a Demographic Analysis and Social Study of Admissions to a Children's Sanatorium (1936-1954) in Stannington, Northumberland" (PDF) (Ph.D. Thesis, Ustinov College). Department of Archaeology, University of Durham.
- Fraser, J. "A study of the types of organisms in a series of bone and joint tuberculosis in children", British Medical Journal, 1913;1:760.
- Fraser, J. An aetiological and pathological study of tuberculosis of the bones and joints. Thesis for degree of MD University of Edinburgh. 1912
- "Surgery at a casualty clearing station". Retrieved 14 April 2018.
- Fraser, J. (9 October 1915). "The Value of Hypochlorous Acid in the Treatment of Gas Gangrene". British Medical Journal. 2 (2858): 525–529. PMC 2303158. PMID 20767843.
- Van Der Kloot, William (2 June 2010). "William Maddock Bayliss's Therapy for Wound Shock" (PDF). Notes and Records of the Royal Society. 64 (3): 271–286. doi:10.1098/rsnr.2009.0068. PMID 20973450.
- "Nature and Treatment of Wound Shock and Allied Conditions". JAMA: The Journal of the American Medical Association. 70 (8): 520. 23 February 1918. doi:10.1001/jama.1918.02600080022008. ISSN 0002-9955. PMC 1523954.(subscription required)
- England, Royal College of Surgeons of. "Wallace, Sir Cuthbert Sidney – Biographical entry – Plarr's Lives of the Fellows Online". livesonline.rcseng.ac.uk. Retrieved 2 April 2018.
- Wallace, Cuthbert; Fraser, John (1918). "Surgery at a Casualty Clearing Station". A & C Black. Retrieved 14 April 2018.
- Biographical Index of Former Fellows of the Royal Society of Edinburgh 1783 – 2002 (PDF). The Royal Society of Edinburgh. July 2006. ISBN 0 902 198 84 X.
- Catford, E.F. (1984). The Royal Infirmary of Edinburgh. Edinburgh: Scottish Academic Press. p. 97.
- Tubbs, Oswald S. (1 July 1944). "The effect of ligation on infection of the patent ductus arteriosus". British Journal of Surgery. 32 (125): 1–12. doi:10.1002/bjs.18003212502. ISSN 1365-2168.(subscription required)
- Gross, Robert; Hubbard, John (1939). "Surgical Ligation of a Patent Ductus Arteriosus". Journal of the American Medical Association. 112 (8): 729. doi:10.1001/jama.1939.02800080049011. ISSN 0002-9955.
- Fye, W. Bruce (2015). Caring for the Heart: Mayo Clinic and the Rise of Specialization. United States: Oxford University Press. p. 230. ISBN 978-0-19-998237-0.
- "Sir John Fraser (1885–1947)". ourhistory.is.ed.ac.uk. Retrieved 31 March 2018.
- "Sir John Fraser Dead". The Glasgow Herald. 2 December 1947. p. 4. Retrieved 1 April 2018.
- Liebermann-Meffert, Dorothea (2001). A century of international progress and tradition in surgery : an illustrated history of the International Society of Surgery. White, Harvey. Heidelberg: Kaden. p. 210. ISBN 978-3922777427. OCLC 49197252.
- "Honorary Fellows of the American College of Surgeons". American College of Surgeons. Retrieved 11 February 2018.
- "LL.D. for Sir John Fraser". The Glasgow Herald. 15 June 1944. p. 2. Retrieved 24 December 2017.