John Graham White
John Graham White
1943 (age 74–75)
|Known for||Research using Caenorhabditis elegans|
|Thesis||Computer aided reconstruction of the nervous system of Caenorhabditis elegans (1975)|
|Doctoral advisor||Sydney Brenner|
|Doctoral students||Richard Durbin|
|Other notable students|
White was educated at Brunel University, where he was awarded an undergraduate degree in Physics in 1969. He went on to study for his PhD at University of Cambridge in 1975 for work on computer-aided reconstruction of the nervous system of Caenorhabditis elegans supervised by Sydney Brenner.
After working at the Laboratory of Molecular Biology, White moved to the University of Wisconsin–Madison in 1993. White's research investigates cell division in the nematode Caenorhabditis elegans. With collaborators Sydney Brenner, John Sulston and others, White co-developed confocal microscopy and mapped the complete nervous system of Caenorhabditis elegans, consisting of 302 neurons and over 7000 synapses. The study was published in 1986 by the Philosophical Transactions of the Royal Society, and is considered[by whom?] to be the first work in the emerging field of connectomes. More recently his research uses:
|“||two collaborative but distinct laboratories, one a biological laboratory that investigates cell division in the nematode Caenorhabditis elegans, and the other an interdisciplinary Biophotonics Instrumentation laboratory that develops new computational and optical techniques for live cell studies.||”|
White identified the first gene with a demonstrated role in determining synaptic specificity. He studied the role of cell–cell interaction in determining the lineage pattern, stimulating a wide field of research. In more recent work, John and his co-workers partially confirmed his earlier model of cytokinesis; they discovered genes controlling cytokinesis and found features previously thought specific to plant cell division. Recognising the potentialities of laser-scanning confocal microscopy, John built a prototype microscope: with William Bradshaw Amos he developed this into a commercially produced instrument now widely used.
Awards and honours
White was the recipient of the Mullard Award in 1994. He was elected a member of the European Molecular Biology Organization (EMBO) in 1994 and a Fellow of the Royal Society (FRS) in 2005.
- White, J. G. (2013). "Getting into the mind of a worm—a personal view". WormBook: 1–10. doi:10.1895/wormbook.1.158.1. PMC 4781474. PMID 23801597.
- "White, John - UW-Engineering Directory, College of Engineering @ The University of Wisconsin-Madison". Archived from the original on 9 December 2013.
- Durbin, Richard Michael (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans (PhD thesis). University of Cambridge. EThOS uk.bl.ethos.233920.
- Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825–836. doi:10.1016/S0092-8674(03)00985-1. PMID 14697201.
- Anon (2005). "Dr John White FRS". London: royalsociety.org. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.
- John Graham White's publications indexed by the Scopus bibliographic database. (subscription required)
- Squirrell, J. M.; Wokosin, D. L.; White, J. G.; Bavister, B. D. (1999). "Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability". Nature Biotechnology. 17 (8): 763–767. doi:10.1038/11698. PMC 5087329. PMID 10429240.
- Kimble, J. E.; White, J. G. (1981). "On the control of germ cell development in Caenorhabditis elegans". Developmental Biology. 81 (2): 208–219. doi:10.1016/0012-1606(81)90284-0. PMID 7202837.
- Chalfie, M.; Eddy, S.; Hengartner, M. O.; Hodgkin, J.; Kohara, Y.; Plasterk, R. H.; Waterston, R. H.; White, J. G. (1995). "Genome maps. VI. Caenorhabditis elegans. Wall chart". Science. 270 (5235): 415–430. doi:10.1126/science.270.5235.410. PMID 7569996.
- White, John (1975). Computer aided reconstruction of the nervous system of Caenorhabditis elegans (PhD thesis). University of Cambridge.
- Hyman, A. A.; White, J. G. (1987). "Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans". The Journal of Cell Biology. 105 (5): 2123–2135. doi:10.1083/jcb.105.5.2123. PMC 2114830. PMID 3680373.
- Podbilewicz, B.; White, J. G. (1994). "Cell fusions in the developing epithelial of C. Elegans". Developmental Biology. 161 (2): 408–424. doi:10.1006/dbio.1994.1041. PMID 8313992.
- White, J.; Strome, S. (1996). "Cleavage plane specification in C. Elegans: How to divide the spoils". Cell. 84 (2): 195–198. doi:10.1016/s0092-8674(00)80974-5. PMID 8565065.
- O'Connell, K. F.; Leys, C. M.; White, J. G. (1998). "A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans". Genetics. 149 (3): 1303–1321. PMC 1460235. PMID 9649522.
- Hird, S. N.; White, J. G. (1993). "Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans". The Journal of Cell Biology. 121 (6): 1343–1355. doi:10.1083/jcb.121.6.1343. PMC 2119718. PMID 8509454.
- White, J. G.; Southgate, E.; Thomson, J. N.; Brenner, S. (1976). "The structure of the ventral nerve cord of Caenorhabditis elegans". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 275 (938): 327–348. doi:10.1098/rstb.1976.0086. PMID 8806.
- White, J. G.; Southgate, E.; Thomson, J. N.; Brenner, S. (1986). "The structure of the nervous system of the nematode Caenorhabditis elegans". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 314 (1165): 1–340. doi:10.1098/rstb.1986.0056. PMID 22462104.
- Sulston, J.; Schierenberg, E.; White, J. G.; Thomson, J. (1983). "The embryonic cell lineage of the nematode Caenorhabditis elegans". Developmental Biology. 100 (1): 64–119. doi:10.1016/0012-1606(83)90201-4. PMID 6684600.