John Hardy (geneticist)

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John Hardy
John Anthony Hardy

(1954-11-09) 9 November 1954 (age 64)[citation needed]
Alma mater
Scientific career
ThesisThe release of amino acids and phenylethylamine from mammalian synaptosomes (1981)

John Anthony Hardy FRS[1] (born 9 November 1954)[citation needed] is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.[3][4][5][6]


Hardy received his Bachelor of Science degree from the University of Leeds in 1976[7] and his PhD from Imperial College London in 1981[7] for research on dopamine and amino acid neuropharmacology.

Career and research[edit]

Following his PhD, Hardy did postdoctoral research at the MRC Neuropathogenesis Unit in Newcastle upon Tyne, England and then further postdoctoral work at the Swedish Brain Bank in Umeå, Sweden where he started to work on Alzheimer's disease.[7]

He became Assistant Professor of Biochemistry at St. Mary's Hospital, Imperial College London in 1985 and initiated genetic studies of Alzheimer's disease there.[8] He became Associate Professor in 1989 and then took the Pfeiffer Endowed Chair of Alzheimer's Research at the University of South Florida, in Tampa in 1992. In 1996 he moved to Mayo Clinic in Jacksonville, Florida, as Consultant and Professor of Neuroscience.

He became Chair of Neuroscience in 2000 and moved to National Institute on Aging, Bethesda, Maryland, as Chief of the Laboratory of Neurogenetics in 2001. In 2007 he took up the Chair of Molecular Biology of Neurological Disease at the Reta Lila Weston Institute of Neurological Studies, University College London.

On 29 November 2015, he was awarded the Breakthrough Prize.

In 2018, Hardy, along with Christian Haass, Bart de Strooper and Michel Goedert, received the Brain Prize for "groundbreaking research on the genetic and molecular basis of Alzheimer’s disease."[9]

Awards and honours[edit]

Among other awards and honours, Hardy has won the Breakthrough Prize in Life Sciences for dissecting the causes of Alzheimer's disease, Parkinson's disease and frontotemporal dementia; the MetLife prize for research into Alzheimer's disease, and the Potamkin Prize for his work in describing the first genetic mutations in the amyloid gene in Alzheimer's disease, in 1991. He was elected a Fellow of the Royal Society (FRS) in 2009.[1]


  1. ^ a b c d "Professor John Hardy FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015.
  2. ^ a b "Professor John Hardy FRS FMedSci".
  3. ^ HARDY, Prof. John. Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
  4. ^ Hutton, Mike; Heutink, Peter; Lendon, Corinne L.; Rizzu, Patrizia; Baker, Matt; Froelich, Susanne; Houlden, Henry; Pickering-Brown, Stuart; Chakraverty, Sumi; Isaacs, Adrian; Grover, Andrew; Hackett, Jennifer; Adamson, Jennifer; Lincoln, Sarah; Dickson, Dennis; Davies, Peter; Petersen, Ronald C.; Stevens, Martijn; de Graaff, Esther; Wauters, Erwin; van Baren, Jeltje; Hillebrand, Marcel; Joosse, Marijke; Kwon, Jennifer M.; Nowotny, Petra; Che, Lien Kuei; Norton, Joanne; Morris, John C.; Reed, Lee A.; Trojanowski, John; Basun, Hans; Lannfelt, Lars; Neystat, Michael; Fahn, Stanley; Dark, Francis; Tannenberg, Tony; Dodd, Peter R.; Hayward, Nick; Kwok, John B. J.; Schofield, Peter R.; Andreadis, Athena; Snowden, Julie; Craufurd, David; Neary, David; Owen, Frank; Oostra, Ben A.; Hardy, John; Goate, Alison; van Swieten, John; Mann, David; Lynch, Timothy (1998). "Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17". Nature. 393 (6686): 702–705. doi:10.1038/31508. ISSN 0028-0836. PMID 9641683.
  5. ^ Goate, Alison; Chartier-Harlin, Marie-Christine; Mullan, Mike; Brown, Jeremy; Crawford, Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise; Mant, Rebecca; Newton, Phillippa; Rooke, Karen; Roques, Penelope; Talbot, Chris; Pericak-Vance, Margaret; Roses, Alien; Williamson, Robert; Rossor, Martin; Owen, Mike; Hardy, John (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. doi:10.1038/349704a0. ISSN 0028-0836. PMID 1671712.
  6. ^ Hardy, J. (2002). "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics". Science. 297 (5580): 353–356. doi:10.1126/science.1072994. ISSN 0036-8075. PMID 12130773.
  7. ^ a b c Neuroscience NIH Archived 10 December 2015 at the Wayback Machine
  8. ^ Archived 5 November 2011 at the Wayback Machine
  9. ^
  10. ^ Devlin, Hannah (6 March 2018). "Brain prize winner calls Brexit a 'disaster' for the NHS and science". The Guardian. Retrieved 2 May 2018.
  11. ^ "John Hardy". Leeds University. July 2017. Retrieved 13 July 2017.
  12. ^ Breakthrough Prize 2016
  13. ^ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 16 March 2015.
  14. ^ "EMBO announces new members for 2015". Heidelberg: European Molecular Biology Organization.
  15. ^ Pritzker, MJ Fox Award for Parkinson Research
  16. ^ "Dan David Prize: LAUREATES 2014: Combatting Memory Loss, JOHN A. HARDY".