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John Hardy (geneticist)

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John Hardy
John Anthony Hardy

(1954-11-09) 9 November 1954 (age 69)[citation needed]
Alma mater
Scientific career
ThesisThe release of amino acids and phenylethylamine from mammalian synaptosomes (1981)

Sir John Anthony Hardy FRS[1] (born 9 November 1954)[citation needed] is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.[3][4][5][6]


Hardy attended St Ambrose College in the late 1960s, where his interest in biochemistry was encouraged by his Biology teacher, Mrs Cox.[7] He received his Bachelor of Science degree from the University of Leeds in 1976[8] and his PhD from Imperial College London in 1981[8] for research on dopamine and amino acid neuropharmacology.

Career and research[edit]

Following his PhD, Hardy did postdoctoral research at the MRC Neuropathogenesis Unit in Newcastle upon Tyne, England and then further postdoctoral work at the Swedish Brain Bank in Umeå, Sweden where he started to work on Alzheimer's disease.[8]

He became Assistant Professor of Biochemistry at St. Mary's Hospital, Imperial College London in 1985 and initiated genetic studies of Alzheimer's disease there.[9] He became Associate Professor in 1989 and then took the Pfeiffer Endowed Chair of Alzheimer's Research at the University of South Florida, in Tampa in 1992. In 1996 he moved to Mayo Clinic in Jacksonville, Florida, as Consultant and Professor of Neuroscience.

He became Chair of Neuroscience in 2000 and moved to National Institute on Aging, Bethesda, Maryland, as Chief of the Laboratory of Neurogenetics in 2001. In 2007 he took up the Chair of Molecular Biology of Neurological Disease at the Reta Lila Weston Institute of Neurological Studies, University College London.

On 29 November 2015, he was awarded the Breakthrough Prize.

In 2018, Hardy, along with Christian Haass, Bart De Strooper and Michel Goedert, received the Brain Prize for "groundbreaking research on the genetic and molecular basis of Alzheimer's disease."[10]

Awards and honours[edit]

Among other awards and honours, Hardy has won the Breakthrough Prize in Life Sciences for dissecting the causes of Alzheimer's disease, Parkinson's disease and frontotemporal dementia; the MetLife prize for research into Alzheimer's disease, and the Potamkin Prize for his work in describing the first genetic mutations in the amyloid gene in Alzheimer's disease, in 1991. He was elected a Fellow of the Royal Society (FRS) in 2009.[1] He was knighted in the 2022 New Year Honours for services to "human health in improving our understanding of dementia and neurodegenerative diseases".[11]


  1. ^ a b c d "Professor John Hardy FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015.
  2. ^ a b "Professor John Hardy FRS FMedSci". Archived from the original on 2 August 2016. Retrieved 27 November 2015.
  3. ^ "HARDY, Prof. John". Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  4. ^ Hutton, Mike; Heutink, Peter; Lendon, Corinne L.; Rizzu, Patrizia; Baker, Matt; Froelich, Susanne; Houlden, Henry; Pickering-Brown, Stuart; Chakraverty, Sumi; Isaacs, Adrian; Grover, Andrew; Hackett, Jennifer; Adamson, Jennifer; Lincoln, Sarah; Dickson, Dennis; Davies, Peter; Petersen, Ronald C.; Stevens, Martijn; de Graaff, Esther; Wauters, Erwin; van Baren, Jeltje; Hillebrand, Marcel; Joosse, Marijke; Kwon, Jennifer M.; Nowotny, Petra; Che, Lien Kuei; Norton, Joanne; Morris, John C.; Reed, Lee A.; Trojanowski, John; Basun, Hans; Lannfelt, Lars; Neystat, Michael; Fahn, Stanley; Dark, Francis; Tannenberg, Tony; Dodd, Peter R.; Hayward, Nick; Kwok, John B. J.; Schofield, Peter R.; Andreadis, Athena; Snowden, Julie; Craufurd, David; Neary, David; Owen, Frank; Oostra, Ben A.; Hardy, John; Goate, Alison; van Swieten, John; Mann, David; Lynch, Timothy (1998). "Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17". Nature. 393 (6686): 702–705. Bibcode:1998Natur.393..702H. doi:10.1038/31508. ISSN 0028-0836. PMID 9641683. S2CID 205001265.
  5. ^ Goate, Alison; Chartier-Harlin, Marie-Christine; Mullan, Mike; Brown, Jeremy; Crawford, Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise; Mant, Rebecca; Newton, Phillippa; Rooke, Karen; Roques, Penelope; Talbot, Chris; Pericak-Vance, Margaret; Roses, Alien; Williamson, Robert; Rossor, Martin; Owen, Mike; Hardy, John (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. Bibcode:1991Natur.349..704G. doi:10.1038/349704a0. ISSN 0028-0836. PMID 1671712. S2CID 4336069.
  6. ^ Hardy, J. (2002). "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics". Science. 297 (5580): 353–356. Bibcode:2002Sci...297..353H. doi:10.1126/science.1072994. ISSN 0036-8075. PMID 12130773. S2CID 15150253.
  7. ^ Keegan (7 January 2022). "Old Boys News - New Year's Honours 2022". Saint Ambrose College Weekly News Bulletin. p. 6. Retrieved 11 January 2022.
  8. ^ a b c Neuroscience NIH Archived 10 December 2015 at the Wayback Machine
  9. ^ HIH.gov Archived 5 November 2011 at the Wayback Machine
  10. ^ thebrainprize.org
  11. ^ "No. 63571". The London Gazette (Supplement). 1 January 2022. p. N2.
  12. ^ Devlin, Hannah (6 March 2018). "Brain prize winner calls Brexit a 'disaster' for the NHS and science". The Guardian. Retrieved 2 May 2018.
  13. ^ "John Hardy". Leeds University. July 2017. Retrieved 13 July 2017.
  14. ^ https://breakthroughprize.org/ Breakthrough Prize 2016
  15. ^ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 16 March 2015.
  16. ^ "EMBO announces new members for 2015". Heidelberg: European Molecular Biology Organization. Archived from the original on 21 March 2016. Retrieved 8 November 2015.
  17. ^ Pritzker, MJ Fox Award for Parkinson Research
  18. ^ "Dan David Prize: LAUREATES 2014: Combatting Memory Loss, JOHN A. HARDY".
  19. ^ "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from the original (PDF) on 13 October 2018.