He matriculated at Magdalene College, Cambridge around 1592, and graduated B.A. in 1596. On 16 March 1598 he entered as a student in the Middle Temple, and on 7 June 1605 he was called to the degree of an utter barrister.
A fellow-student, Edward, son of William Curll and brother of Walter Curll, obtained for him the post of auditor of the court of wards. He was also befriended by a distant relative, Richard Manningham, who, born at St Albans in 1539, made a fortune in London as a mercer, and in his old age retired to Bradbourne, near Maidstone. Richard Manningham died on 25 April 1611, and was buried in East Malling Church, where John Manningham erected a monument to his memory. To John, his sole executor, Richard left his house and lands in Kent.
Manningham wrote a diary, preserved among the Harleian Manuscripts, and first printed by the Camden Society in 1868, under the editorship of John Bruce. It covers the period from January 1602 to April 1603; at the time the writer was a student in the Middle Temple. The work is a medley of anecdotes of London life, political rumours, accounts of sermons, and memoranda of journeys. The gossip respecting Queen Elizabeth's illness and death and the accession of James I is set down in detail, and Manningham often supplies comments on the character of the chief lawyers and preachers of the day. He also gives an account of the performance of Shakespeare's Twelfth Night on 2 February 1602 in the Middle Temple Hall. John Payne Collier first called attention to Manningham's work. The anecdote of Shakespeare's triumph over Richard Burbage in the pursuit of the favours of a lady of doubtful virtue rests on Manningham's authority. Sir Thomas Bodley, John Stow, and Sir Thomas Overbury are also occasionally mentioned by Manningham.
Manningham married, about 1607, Ann, sister of his friend Curll. By her he had three sons, Richard (born 1608), John (born 1616), and Walter, and three daughters, Susannah, Ann, and Elizabeth. Walter Curll, by his will of 15 March 1646–7, left legacies to his sister Mrs. Manningham and her son and his godson Walter. She was dead before 1656, when her eldest son Richard sold the property at Bradbourne to Thomas Twysden, serjeant-at-law.
- "Manningham, John (MNNN592J)". A Cambridge Alumni Database. University of Cambridge.
- In his Annals of the Stage, 1831, i. 320.
- This article incorporates text from a publication now in the public domain: "Manningham, John". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.